難治性慢性疼痛患者へのクエチアピンの使用経験

DOI Web Site 参考文献9件
  • 黒川 博己
    Department of Anesthesiology and Critical Care Medicine, Hiroshima University Hospital
  • 仁井内 浩
    Department of Anesthesiology and Critical Care Medicine, Hiroshima University Hospital
  • 中布 龍一
    Department of Anesthesiology and Critical Care Medicine, Hiroshima University Hospital
  • 河本 昌志
    Department of Anesthesiology and Critical Care Medicine, Hiroshima University Hospital
  • 弓削 孟文
    Department of Anesthesiology and Critical Care Medicine, Hiroshima University Hospital

書誌事項

タイトル別名
  • A report of application of quetiapine fumarate for patients with intractable chronic pain
  • ショウレイ ナンジセイ マンセイ トウツウ カンジャ エ ノ クエチアピン ノ シヨウ ケイケン

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抄録

Antipsychotic drugs are sometimes necessary as a adjuvant analgesic for patients with intractable chronic pain. We report 3 cases in which improvements in QOL, previously reduced by pain, were seen following the use of quetiapine fumarate, an atypical antipsychotic. Quetiapine fumarate is a serotonin dopamine antagonist that has both antiserotonin and antidopaminergic actions, and is presumed to improve both positive (delusion, agitation) and negative (apathy, reduced thinking, hypobulia) symptoms. The degree of pain was reduced in only one of the patients; therefore, the direct analgesic effect remains unknown. However, from our results, we consider that the QOL could be improved by the use of quetiapine fumarate through amelioration of such symptoms as nocturnal unrest and low level of motivation to live in patients with intractable chronic pain.

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