術後イレウスモデルに対する数種漢方処方の作用  [in Japanese] Effects of Several Kampo Medicines on Postoperative Ileus Model  [in Japanese]

人参湯,半夏瀉心湯,六君子湯および小半夏加茯苓湯について,ラット術後イレウスモデルに対する作用を調べた。ラットをエーテル麻酔下に開腹した後,小腸および盲腸を腹腔外に5分間露呈させることで術後イレウスモデルを作製した。このイレウスモデルでは,活性炭末マーカーの輸送率を計測することで評価した腸管運動が,麻酔処置のみの動物に比べて著しく低下した。消化管運動促進薬のシサプリド,モサプリド,メトクロプラミド,抗炎症薬のインドメタシン,および臨床で術後イレウスに用いられている漢方処方である大建中湯は,いずれもControl群に比べて炭末マーカーの輸送能を有意に増加した。今回検討した漢方処方では,六君子湯および小半夏加茯苓湯はほとんど無効であったが,人参湯および半夏瀉心湯はControl群に比べて腸管運動を有意に改善し,それら処方の効果は大建中湯よりも強かった。

The effects of four Kampo medicines, Ninjin-to, Hange-shashin-to, Rikkunshi-to and Sho-hange-ka-bukuryo-to, were investigated in a rat model of postoperative ileus. The postoperative ileus model was made by incising the abdomen and exposing the small intestine and caecum for five minutes under ether anesthesia. The gastrointestinal transit was estimated by the migration of a charcoal marker. In contrast to the animals anesthetized only, the gastrointestinal transit was markedly decreased in control animals. First, we studied the gastrointestinal prokinetic drugs (cisapride, mosapride and metoclopramide), the anti-inflammatory drug indomethacin, and the Kampo medicine Dai-kenchu-to in this model. They significantly increased the transit as compared with the control. Using the same method, Rikkunshi-to and Sho-hange-ka-bukuryo-to were demonstrated to be almost inactive. However, Ninjin-to and Hange-shashin-to not only significantly improved the gastrointestinal mobility compared to the control, but also showed stronger effects than those of Dai-kenchu-to. These results suggest that in addition to Dai-kenchu-to, Ninjin-to and Hange-shashin-to are also effective Kampo medicines for postoperative ileus.