An Optimal Cutoff Point of Expired-Air Carbon Monoxide Levels for Detecting Current Smoking: in the Case of a Japanese Male Population whose Smoking Prevalence was Sixty Percent

  • Nakayama Takeo
    Department of Epidemiology, Medical Research Institute, Tokyo Medical and Dental University
  • Yamamoto Akio
    Department of Epidemiology, Medical Research Institute, Tokyo Medical and Dental University Department of Epidemiological Information, Hyogo Prefectural Institute of Health
  • Ichimura Takayoshi
    Department of Epidemiology, Medical Research Institute, Tokyo Medical and Dental University
  • Yoshiike Nobuo
    Division of Adult Health Science, National, Institute of Health and Nutrition
  • Yokoyama Tetsuji
    Department of Epidemiology, Medical Research Institute, Tokyo Medical and Dental University
  • Fujimoto Edward K.
    Division of Health Education, Tokyo Adventist Hospital
  • Tanaka Heizo
    Department of Epidemiology, Medical Research Institute, Tokyo Medical and Dental University

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An optimal cutoff point of expired-air carbon monoxide (Ex-CO) for detecting smokers should be determined in terms of its sensitivity and specificity and the prevalence of smoking in the target population. The purpose of this study is to determine the optimal cutoff point of Ex-CO for detecting smoking males in a Japanese community whose smoking prevalence was over 50%. Among free-living residents in a rural population, "true smokers" determined by presence of cotinine in serum were 61 % (n=94). When Ex-CO at 7 ppm or over differentiated "smokers" from "non-smokers", sensitivity and specificity for detecting smokers was 0.93 and 0.95, respectively, which comprised the best Youden's index. This setting also produced the minimum percentage of misclassified cases. In conclusion, 7 ppm of Ex-CO, which is exceptionally low value relative to the western standard, appears to be the most optimal cutoff point for a survey in a population with such high smoking prevalence. J Epidemiol, 1998 ; 8 : 140-145.

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