多発性骨髄腫(IgA-κ)の経過中IgAリウマトイド因子(RF)が出現した1例

• 西成田 真

  多賀総合病院リウマチ膠原病センター

• 柏崎 禎夫

  東京女子医科大学膠原病リウマチ痛風センター

• 菅井 進

  金沢医科大学血液免疫内科

書誌事項

タイトル別名

• Monoclonal rheumatoid factor in a patient with multiple myeloma after chemotherapy.

抄録

A patient with multiple myeloma was treated with several cycles of chemotherapy and developed monoclonal IgA rheumatoid factor.<br> The monoclonal rheumatoid factor in this case reacted with 2 types of monoclonal antiidiotypic antibody derived from monoclonal rheumatoid factors in a patient with Sjögren's syndrome and a patient with macroglobulinemia.<br> Two possible mechanisms accounting for the developement of rheumatoid factor activity during a course of chemotherapy are discussed. The first possibility is that the rheumatoid factor or activity had been initially covered by an antiidiotypic antibody but was disclosed by the decreased production of this antibody following by the immunosuppressive therapy. The second possibility is that monoclonal IgA acquired rheumatoid factor activity by a point mutation resulting in a change in the molecular structure of the idiotype.

収録刊行物

• 日本臨床免疫学会会誌

  日本臨床免疫学会会誌 19 (5), 519-523, 1996

  日本臨床免疫学会

キーワード

• rheumatoid factor
• M protein
• antiidiotype antibody

詳細情報

• CRID: 1390001204649767040
• NII論文ID: 10016359141
• NII書誌ID: AN00357971
• DOI: 10.2177/jsci.19.519
• ISSN: 13497413
• ISSN: 09114300
• PubMed: 8952321
• Web Site: http://www.jstage.jst.go.jp/article/jsci1978/19/5/19_5_519/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1997070768
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可