Differential stereoselective effects of levobupivacaine, bupivacaine and dexbupivacaine on the heart in isolated rat hearts

• Urashima Kazuya

  Department of Clinical Pharmacy and Clinical Pharmacokinetics, Osaka University of Pharmaceutical Sciences

• Sohma Yoshiro

  Department of Physiology, Osaka Medical College

• Ijiri Yoshio

  Department of Pharmacy, Osaka Medical College Hospital

• Terai Shiori

  Department of Hygienic Chemistry, Osaka University of Pharmaceutical Sciences

• Umeda Takashi

  Department of Clinical Acupuncture, Kansai College of Oriental Medicine

• Kawakami Yuka

  Department of Clinical Pharmacy and Clinical Pharmacokinetics, Osaka University of Pharmaceutical Sciences

• Nishihori Takako

  Department of Clinical Pharmacy and Clinical Pharmacokinetics, Osaka University of Pharmaceutical Sciences

• Hirotani Yoshihiko

  Department of Clinical Pharmacy and Clinical Pharmacokinetics, Osaka University of Pharmaceutical Sciences

• Tanaka Kazuhiko

  Department of Clinical Pharmacy and Clinical Pharmacokinetics, Osaka University of Pharmaceutical Sciences

抄録

Bupivacaine(BUP) has an advantage over other local anesthetics because of its long-acting sensory anesthesia, but because of its high affinity for the myocardial Na⁺ channel it can be cardiotoxic. Levobupivacaine(LBUP) is an S(-)-isomer of the racemate BUP, and dexbupivacaine(DBUP) is an R(+)-isomer. LBUP has less neuronal and cardiac toxicity than BUP and DBUP, but DBUP induces more negative chronotropism and arrhythmogenic effects than either LBUP or BUP.<BR>

収録刊行物

• 循環制御

  循環制御 26 (2), 140-147, 2005

  日本循環制御医学会

キーワード

• bupivacaine
• levobupivacaine
• dex-bupivacaine
• heart rate
• ion

詳細情報

• CRID: 1390282679081536000
• NII論文ID: 10016425062
• NII書誌ID: AN00357563
• DOI: 10.11312/ccm.26.140
• ISSN: 03891844
• Web Site: https://search.jamas.or.jp/link/ui/2006022368
• 本文言語コード: en
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可