細胞壁生合成を利用したバクテリア人工機能化

  • Sadamoto Reiko
    Shionogi Laboratory of Biomolecular Chemistry, Division of Biological Sciences, Graduate School of Science, Frontier Research Center for Post-Genomic Science and Technology, Hokkaido University

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タイトル別名
  • Artificial Modification of Bacterial Surface with Cell-Wall Engineering
  • サイボウヘキ セイゴウセイ オ リヨウ シタ バクテリア ジンコウ キノウカ ガン エイブン

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This article deals with cell-surface engineering using bacterial cell wall aiming for the development of new mucosal vaccines. We developed a method for artificial modification of live bacteria. As precursors to be incorporated into bacterial cell wall, muramic acid derivatives with ketone moiety were synthesized. When the synthesized precursor was added to growth media, it was transferred through biosynthetic pathway of the cell wall and the ketone group was displayed on the surface of bacteria. Examples of bacterial surface modifications by this method are described.

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