血性乳頭分泌を伴った乳腺adenomyoepitheliomaの1例

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  • A CASE OF ADENOMYOEPITHELIOMA OF THE BREAST WITH BLOODY NIPPLE DISCHARGE

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A 22-year-old woman visited our hospital because of bloody nipple discharge of the right breast. An ill-defined mass, about 15mm in diameter, was palpable in the B area of the right breast, but ultrasonography and mammography showed no apparent abnormal findings. Ductography showed an obstruction and multiple filling defects of the peripheral ducts. The tumor was suspected to be intraductal papillomatosis and a duct-lobular segmentectomy was performed. Histological examination showed bicellular proliferation of epithelial cells and myoepithelial cells in the ducts. The tumor was diagnosed as adenomyoepithelioma (AME) by immunohistochemical examination, which showed epithelial cells were positive for EMA and myoepithelial cells were positive for α-SMA. Generally AME is considered a benign tumor. However, a few cases with local recurrences or distant metastases have been reported. AME of the breast is an extremely rare tumor and still has many unsolved problems. In this case we could detect multiple tumors in the ducts by ductography because the chief complaint was bloody nipple discharge. This case suggests that in treating we need to consider the intraductal spread of AME even if the tumor is histologically benign.

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