Peripheral Vascular Endothelial Function in Essential Hyperhidrosis

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  • Esen Ali Metin
    Kosuyolu Heart Education and Research Hospital, Department of Cardiology
  • Barutcu Irfan
    Kosuyolu Heart Education and Research Hospital, Department of Cardiology
  • Karaca Semsettin
    Kocatepe University Faculty of Medicine, Department of Dermatology
  • Kaya Dayimi
    Kocatepe University Faculty of Medicine, Department of Cardiology
  • Kulac Mustafa
    Kocatepe University Faculty of Medicine, Department of Dermatology
  • Esen Ozlem
    Istanbul Memorial Hospital Department of Cardiology
  • Karakaya Osman
    Kosuyolu Heart Education and Research Hospital, Department of Cardiology
  • Melek Mehmet
    Kocatepe University Faculty of Medicine, Department of Cardiology
  • Onrat Ersel
    Kocatepe University Faculty of Medicine, Department of Cardiology
  • Celik Atac
    Kocatepe University Faculty of Medicine, Department of Cardiology
  • Kilit Celal
    Kocatepe University Faculty of Medicine, Department of Cardiology

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Background Essential hyperhidrosis, a disorder of the eccrine sweat glands, is associated with sympathetic overactivity and the aim of the present study was to determine endothelium-dependent vasodilator function in patients with this condition. Methods and Results Using high-resolution ultrasound, the diameter of the brachial artery at rest and during reactive hyperemia (flow-mediated dilatation, %FMD endothelial-dependent stimulus to vasodilatation), as well as after sublingual administration of nitroglycerin (%NTG endothelium-independent vasodilatation) was measured in 18 subjects (mean age 27±5 years) with essential hyperhidrosis and 24 healthy control subjects (mean age 29±5 years). Baseline brachial artery diameter and FMD were comparable in both groups (BAD: 4.1±0.7 mm vs 4.3±0.5 mm (control), p=0.8; FMD: 5.6±1.9% vs 6.7±2.2%, p=0.1). The time-averaged flow velocity during peak reactive hyperemia was similar in the 2 groups (75±11 cm/s vs 72±10 cm/s, p=0.5), nor did NTG-induced dilatation in the patients with essential hyperhidrosis differ significantly from that in healthy control subjects (12.8±2.7% vs 14.0±3.6%, p=0.3). Conclusion These findings suggest that endothelium-dependent dilatation of large conduit arteries is preserved in essential hyperhidrosis and it seems to be a localized disorder of the eccrine sweat glands rather than a generalized disorder involving vascular endothelium. (Circ J 2005; 69: 707 - 710)<br>

収録刊行物

  • Circulation Journal

    Circulation Journal 69 (6), 707-710, 2005

    一般社団法人 日本循環器学会

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