Predictability of O2 Consumption from Contractility and Mechanical Energy of Absolute Arrhythmic Beats in Canine Heart

DOI Web Site PubMed 被引用文献3件 参考文献29件
  • Shimizu Juichiro
    Department of Cardiovascular Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
  • Mohri Satoshi
    Department of Cardiovascular Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
  • Iribe Gentaro
    Department of Cardiovascular Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
  • Ito Haruo
    Department of Cardiovascular Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
  • Morita Terumasa
    Department of Cardiovascular Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
  • Yamaguchi Hiroki
    Department of Cardiovascular Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
  • Sano Shunji
    Department of Cardiovascular Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
  • Suga Hiroyuki
    Department of Cardiovascular Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science National Cardiovascular Center Research Institute

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Left ventricular (LV) O2 consumption (Vo2) per minute is measurable for both regular and arrhythmic beats. LV Vo2 per beat can then be obtained as Vo2 per minute minute divided by heart rate per minute minute for regular beats, but not for arrhythmic beats. We have established that Vo2 of a regular stable beat is predictable by Vo2 = a PVA + b Emax + c, where PVA is the systolic pressure-volume area as a measure of the total mechanical energy of an individual contraction and Emax is the end-systolic maximum elastance as an index of ventricular contractility of the contraction. Furthermore, a is the O2 cost of PVA, b is the O2 cost of Emax, and c is the basal metabolic Vo2 per beat. We considered it theoretically reasonable to expect that the same formula could also predict LV Vo2 of individual arrhythmic beats from their respective PVA and Emax with the same a, b, and c. We therefore applied this formula to the PVA - Emax data of individual arrhythmic beats under electrically induced atrial fibrillation (AF) in six canine in situ hearts. We found that the predicted Vo2 of individual arrhythmic beats highly correlated linearly with either their Vo2 (r = 0.96 ± 0.01) or Emax (0.97 ± 0.03) while both also highly correlated linearly with each other (0.88 ± 0.04). This suggests that the above formula may be used to predict LV Vo2 of absolute arrhythmic beats from their Emax and PVA under AF.<br>

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