Synthesis and Pharmacological Activity of 4-(4'-(Chlorophenyl)-4-hydroxypiperidine) Derivatives

    • SAIFY Zafar Saeed
    • HEJ Research Institute of Chemistry, International Centre for Chemical Sciences, University of Karachi
    • MUSHTAQ Nousheen
    • HEJ Research Institute of Chemistry, International Centre for Chemical Sciences, University of Karachi
    • KHAN Khalid Mohammed
    • HEJ Research Institute of Chemistry, International Centre for Chemical Sciences, University of Karachi
    • SHAH Syed Tasadaque Ali
    • Abteilung fur Physikalische Biochemie des Physiologisch-chemischen Instituts der Universitat Tubingen
    • FECKER Miriam
    • Abteilung fur Physikalische Biochemie des Physiologisch-chemischen Instituts der Universitat Tubingen
    • VOELTER Wolfgang
    • Abteilung fur Physikalische Biochemie des Physiologisch-chemischen Instituts der Universitat Tubingen

Abstract

A new series of 4-(4'-chlorophenyl)-4-hydroxypiperidine derivatives (2-5), substituted at nitrogen, were synthesized and tested as potential analgesic compounds as well as evaluated for their effect on hypotensive activity. Results showed that all the derivatives exhibit significant analgesic activity in male Wistar rats at a dose of 50 mg/kg of body weight after intramuscular injection, when tested by thermal stimuli (tail flick test). Pethidine was used as reference drug. Compounds 2,3 and 5 produced reduction in blood pressure in normotensive rat.

Journal

Chemical & pharmaceutical bulletin   [List of Volumes]

Chemical & pharmaceutical bulletin 53(1), 64-66, 2005-01-01  [Table of Contents]

The Pharmaceutical Society of Japan

References:  14

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Codes

  • NII Article ID (NAID) :
    10016651515
  • NII NACSIS-CAT ID (NCID) :
    AA00602100
  • Text Lang :
    ENG
  • Article Type :
    ART
  • ISSN :
    00092363
  • NDL Article ID :
    7200830
  • NDL Source Classification :
    ZS51(科学技術--薬学) // ZP1(科学技術--化学・化学工業)
  • NDL Call No. :
    Z53-D167
  • DOI :
    10.1248/cpb.53.64
  • Databases :
    CJP  NDL  NII-ELS  J-STAGE