Preparation of 2-Pyridone-Containing Tricyclic Alkaloid Derivatives as Potential Inhibitors of Tumor Cell Proliferation by Regioselective Intramolecular N- and C-Acylation of 2-Pyridone

Abstract

A novel and practical preparation of 2-pyridone-containing tricyclic alkaloid derivatives was developed. By regioselective intramolecular N- and C-acylation of 2-(4-aryl-2-pyridon-6-yl) benzoic acid, a pair of structural isomers 2-aryl pyrido [2,1-a] isoindole-4,6-diones and 4-aryl 1-methyl-1H-indeno [1,2-b] -pyridine-2,5-diones, as potential inhibitors of tumor cell proliferation, were prepared respectively.

Journal

Chemical & pharmaceutical bulletin   [List of Volumes]

Chemical & pharmaceutical bulletin 53(1), 67-71, 2005-01-01  [Table of Contents]

The Pharmaceutical Society of Japan

References:  49

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Codes

  • NII Article ID (NAID) :
    10016651530
  • NII NACSIS-CAT ID (NCID) :
    AA00602100
  • Text Lang :
    ENG
  • Article Type :
    ART
  • ISSN :
    00092363
  • NDL Article ID :
    7200859
  • NDL Source Classification :
    ZS51(科学技術--薬学) // ZP1(科学技術--化学・化学工業)
  • NDL Call No. :
    Z53-D167
  • DOI :
    10.1248/cpb.53.67
  • Databases :
    CJP  NDL  NII-ELS  J-STAGE