Tyrosinase-Inhibitory Long-Chain Esters from Amberboa ramosa

    • KHAN Sher Bahadar
    • International Center for Chemical Sciences, H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research, University of Karachi
    • HAQ AZHAR-UL
    • International Center for Chemical Sciences, H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research, University of Karachi
    • AFZA Nighat
    • Pharmaceutical Research Centre, PCSIR Labs-Complex Karachi
    • MALIK Abdul
    • International Center for Chemical Sciences, H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research, University of Karachi
    • KHAN Mahmud Tariq Hasan
    • International Center for Chemical Sciences, H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research, University of Karachi
    • SHAH Muhammad Raza
    • International Center for Chemical Sciences, H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research, University of Karachi
    • CHOUDHARY Muhammad Iqbal
    • International Center for Chemical Sciences, H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research, University of Karachi

Abstract

Long-chain esters 1 and 2 have been isolated from the chloroform-soluble fraction of Amberboa ramosa and their structures assigned to be methyl 2β(2S)-hydroxyl-7(E)-tritriacontenoate (1) and methyl 2β(2S)-O-β-D-galactopyranosyl-7(E)-tetratriacontenoate (2). In addition, tricontane (3) and apigenin (4) are also reported for the first time from this species. The structures were assigned on the basis of 1D and 2D NMR techniques. Compounds 1 and 2 showed strong to moderate inhibitory activity against tyrosinase.

Journal

Chemical & pharmaceutical bulletin   [List of Volumes]

Chemical & pharmaceutical bulletin 53(1), 86-89, 2005-01-01  [Table of Contents]

The Pharmaceutical Society of Japan

References:  17

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Codes

  • NII Article ID (NAID) :
    10016651612
  • NII NACSIS-CAT ID (NCID) :
    AA00602100
  • Text Lang :
    ENG
  • Article Type :
    NOT
  • ISSN :
    00092363
  • NDL Article ID :
    7200949
  • NDL Source Classification :
    ZS51(科学技術--薬学) // ZP1(科学技術--化学・化学工業)
  • NDL Call No. :
    Z53-D167
  • DOI :
    10.1248/cpb.53.86
  • Databases :
    CJP  NDL  NII-ELS  J-STAGE