Complete NMR Assignments of the Antibacterial Biflavonoid GB1 from Garcinia kola

    • HAN Quan Bin
    • Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine
    • LEE Song Fong
    • Department of Applied Oral Sciences, Faculty of Dentistry, Dalhousie University
    • QIAO Chun Feng
    • Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine
    • HE Zhen Dan
    • Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine
    • SONG Jing Zheng
    • Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine
    • SUN Han Dong
    • State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences
    • XU Hong Xi
    • Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine

Abstract

From the antibacterial fraction of the roots of Garcinia kola, 3", 4', 4''', 5, 5", 7, 7"-heptahydroxy-3, 8"-biflavanone (GB1) was isolated as the major constituent, whose interesting conformations were studied on the basis of its 1D and 2D NMR spectra obtained at different temperatures and in different solvents. GB1 showed antibacterial activities against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) with MIC of 32 and 128μg/ml, respectively.

Journal

Chemical & pharmaceutical bulletin   [List of Volumes]

Chemical & pharmaceutical bulletin 53(8), 1034-1036, 2005-08-01  [Table of Contents]

The Pharmaceutical Society of Japan

References:  15

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Cited by:  1

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Codes

  • NII Article ID (NAID) :
    10016656189
  • NII NACSIS-CAT ID (NCID) :
    AA00602100
  • Text Lang :
    ENG
  • Article Type :
    Journal Article
  • ISSN :
    00092363
  • NDL Article ID :
    7373189
  • NDL Source Classification :
    ZS51(科学技術--薬学) // ZP1(科学技術--化学・化学工業)
  • NDL Call No. :
    Z53-D167
  • Databases :
    CJP  CJPref  NDL  NII-ELS  J-STAGE 

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