Pharmacological Properties of Traditional Medicine(30)Effects of Gyokuheifusan (玉屏風散) on Murine Antigen-Specific Antibody Production

• Makino Toshiaki

  Department of Kampo Medicinal Science, Hokkaido College of Pharmacy

• Sasaki Shin-ya

  Department of Kampo Medicinal Science, Hokkaido College of Pharmacy

• Ito Yoshiaki

  Department of Kampo Medicinal Science, Hokkaido College of Pharmacy

• Kano Yoshihiro

  Department of Kampo Medicinal Science, Hokkaido College of Pharmacy

書誌事項

タイトル別名

• Pharmacological Properties of Traditional Medicine (XXX): Effects of Gyokuheifusan on Murine Antigen-Specific Antibody Production
• Pharmacological Properties of Traditional Medicine 30 Effects of Gyokuheifusan ギョク ヘイフウサン on Murine Antigen Specific Antibody Production

抄録

In the theory of traditional Chinese medicine (TCM), eqi (衛気) circulates at the superficial portion of the body to guard against exopathogen. Gyokuheifusan (GHS; 玉屏風散), containing Astragalus Root, Atractylodes Rhizome, and Saposhnikovia Root, is a TCM formula to treat the insufficiency of eqi by invigorating qi and consolidating the superficial resistance. In this study, we evaluated the effect of GHS on murine antibody production against ovalbumin (OVA) used as exopathogen. Balb/c mice were sensitized with OVA and alum via intraperitoneal (i.p.) injection or intranasal (i.n.) infusion daily for 7 d. GHS was orally administered daily at the dose of 10-times amount of human daily dosage from 3 d before the sensitization for 14 d. Fourteen d after the final sensitization, the blood was collected, and the concentrations of OVA-specific or non-specific immunoglobulins were measured. When OVA was sensitized i.p., the concentration of OVA-specific IgG, IgG₁, IgG_2a and IgA in the sera significantly increased by GHS-treatment. When OVA was sensitized i.n., GHS significantly reduce the concentration of OVA-specific IgG and IgG₁ in the sera. Non-specific immunoglobulins were not changed by GHS-treatment. It is suggested that GHS could stimulate immune responses when antigen had already been invaded into the inside of the body, and that GHS might consolidate the resistance of nasal mucosa to protect from the invasion of OVA, then OVA-specific antibodies in sera might be hypocritically suppressed. The present study might provide the experimental evidence for TCM theory.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 28 (1), 110-113, 2005

  公益社団法人 日本薬学会

キーワード

• <i>Gyokuheifusan</i>
• <i>Astragalus membranaceus</i>
• traditional Chinese medicine
• kampo medicine
• allergic rhinitis
• immunomodulation

詳細情報

• CRID: 1390282679604568832
• NII論文ID: 10016658951
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.28.110
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 7201221
• PubMed: 15635173
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7201221
• Web Site: http://www.jstage.jst.go.jp/article/bpb/28/1/28_1_110/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2006233322
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可