Inhibitory Effect of Ginsenoside Rb1 and Compound K on NO and Prostaglandin E2 Biosyntheses of RAW264.7 Cells Induced by Lipopolysaccharide
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- Park Eun-Kyung
- College of Pharmacy, Kyung Hee University
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- Shin Yong-Wook
- College of Pharmacy, Kyung Hee University
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- Lee Hae-Ung
- College of Pharmacy, Kyung Hee University
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- Kim Sung-Soo
- Korea Food Research Institute
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- Lee Young-Churl
- Korea Food Research Institute
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- Lee Boo-Yong
- Korea Food Research Institute
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- Kim Dong-Hyun
- College of Pharmacy, Kyung Hee University
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In this study, the antiinflammatory activities of ginsenoside Rb1, which is a main constituent of the root of Panax ginseng (Araliaceae), and of its metabolite compound K, as produced by human intestinal bacteria, on lipopolysaccharide (LPS)-induced RAW264.7 cells were investigated. Compound K potently inhibited the production of NO and prostaglandin E2 in LPS-induced RAW 264.7 cells, with IC50 values of 0.012 and 0.004 mM, respectively. Compound K also reduced the expression levels of the inducible NO synthase (iNOS) and COX-2 proteins and inhibited the activation of NF-kB, a nuclear transcription factor. Compound K inhibited the NO level produced by iNOS enzyme activity in a cell-free system, but did not inhibit COX-1 and 2 activities. When ginsenoside Rb1 was orally administered to rats, compound K, but not ginsenoside Rb1, were excreted in their urine. These findings suggest that ginsenoside Rb1 can be transformed to compound K by intestinal bacteria, and compound K may be effective against inflammation.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 28 (4), 652-656, 2005
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679602838656
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- NII論文ID
- 10016662214
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- NII書誌ID
- AA10885497
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- COI
- 1:CAS:528:DC%2BD2MXksFagsrk%3D
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 7292411
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- PubMed
- 15802804
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可