Limited Role of P-Glycoprotein in the Intestinal Absorption of Cyclosporin A
-
- Lee Young-Joo
- Department of Pharmaceutics, College of Pharmacy, Seoul National University, Korea
-
- Chung Suk-Jae
- Department of Pharmaceutics, College of Pharmacy, Seoul National University, Korea
-
- Shim Chang-Koo
- Department of Pharmaceutics, College of Pharmacy, Seoul National University, Korea
この論文をさがす
抄録
The contribution of P-glycoprotein (P-gp) to the intestinal absorption of cyclosporin A (CsA) was investigated by comparing the in vivo pharmacokinetics of CsA in P-gp knockout mice versus wild-type mice following both oral and intravenous administration and by examining the transport of CsA across Caco-2 cell monolayers. The apparent oral bioavailability of CsA in P-gp knockout mice was 1.55-fold larger than in wild-type mice, leading to an apparent absolute bioavailability of 41.8%. A concentration dependent efflux transport of CsA across Caco-2 cell monolayers was found, which exhibited saturation at a CsA concentration of 1 μM. These results suggest that the involvement of P-gp in the intestinal absorption of CsA is not as profound as was previously thought.
収録刊行物
-
- Biological & Pharmaceutical Bulletin
-
Biological & Pharmaceutical Bulletin 28 (4), 760-763, 2005
公益社団法人 日本薬学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390282679602924032
-
- NII論文ID
- 10016662804
-
- NII書誌ID
- AA10885497
-
- ISSN
- 13475215
- 09186158
-
- NDL書誌ID
- 7292539
-
- PubMed
- 15802827
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可