Inhibitory Effects of Fungal Bis(naphtho-γ-pyrone) Derivatives on Nitric Oxide Production by a Murine Macrophage-Like Cell Line, RAW 264.7, Activated by Lipopolysaccharide and Interferon-γ

• Ishii Rie

  Saitama Institute of Public Health

• Horie Masakazu

  Saitama Institute of Public Health

• Koyama Kiyotaka

  Department of Pharmacognosy and Phytochemistry, Meiji Pharmaceutical University

• Ishikawa Yukihiro

  Faculty of Regional Sciences, Tottori University

• Kitanaka Susumu

  College of Pharmacy, Nihon University

書誌事項

タイトル別名

• Inhibitory Effects of Fungal Bis(naphtho-.GAMMA.-pyrone) Derivatives on Nitric Oxide Production by a Murine Macrophage-Like Cell Line, RAW 264.7, Activated by Lipopolysaccharide and Interferon-.GAMMA.
• Inhibitory Effects of Fungal Bis naphtho ガンマ pyrone Derivatives on Nitric Oxide Production by a Murine Macrophage Like Cell Line RAW 264 7 Activated by Lipopolysaccharide and Interferon ガンマ

抄録

Inhibitory effects of six fungal bis(naphtho-γ-pyrone) derivatives on nitric oxide (NO) production by a murine macrophage-like cell line, RAW 264.7, which was activated by lipopolysaccharide and interferon-γ were examined. Among these derivatives, chaetochromin (4) (IC₅₀: 0.8 μM), cephalochromin (1) (IC₅₀ 1.5 μM), and dihydroisoustilaginoidin A (6) (IC₅₀ 2.8 μM) exhibited strong inhibitory activity. The bis(naphtho-γ-pyrone) derivatives did not affect the enzyme activity of inducible nitric oxide synthase (iNOS). However, these derivatives significantly reduced both the induction of iNOS protein and iNOS mRNA expression. These results suggest that the bis(naphtho-γ-pyrone) derivatives have the pharmacologic ability to suppress NO production by activated macrophages.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 28 (5), 786-790, 2005

  公益社団法人 日本薬学会

キーワード

• naphtho-γ-pyrone
• macrophage
• nitric oxide
• cephalochromin
• chaetochromin

詳細情報

• CRID: 1390001204626802176
• NII論文ID: 10016662973
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.28.786
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 7304530
• PubMed: 15863879
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7304530
• Web Site: http://www.jstage.jst.go.jp/article/bpb/28/5/28_5_786/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2006261976
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可