In vitro study of the adsorption characteristic of drugs
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- Toyoguchi Teiko
- Department of Pharmacy, Yamagata University Hospital
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- Ebihara Mitsutaka
- Department of Pharmacy, Yamagata University Hospital
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- Ojima Fumiyoshi
- Department of Pharmacy, Yamagata University Hospital
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- Hosoya Jun
- Department of Pharmacy, Yamagata University Hospital
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- Nakagawa Yoshito
- Department of Pharmacy, Yamagata University Hospital
書誌事項
- タイトル別名
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- In Vitro Study of the Adsorption Characteristics of Drugs
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The adsorption characteristics of eight adsorbents, cholestyramine, colestimide, aluminum silicate, sucralfate, aluminum hydroxide, calcium polystyrene sulfonate, carbon sphere and medicinal carbon, on the drugs such as methotrexate, antidepressants, mizoribine and ciprofloxacin hydrochloride were investigated in vitro. Medicinal carbon showed an excellent adsorption of all the tested drugs while the carbon spheres showed a high but slow adsorption characteristic. Cholestyramine and colestimide showed a higher adsorption in methotrexate than the other adsorbents. Aluminum silicate and calcium polystyrene sulfonate showed higher adsorption in four antidepressants, clomipramine hydrochloride, imipramine hydrochloride, mianserin hydrochloride and trazodone hydrochloride. In mizoribine, there were no adsorbents that showed higher adsorption except for the medicinal carbon. In ciprofloxacin hydrochloride, aluminum preparations and calcium polystyrene sulfonate showed higher adsorption characteristics. It is suggested that several adsorbents are potentially useful treatments for drug overdoses, but that these adsorbents have the possibility of decreasing the effects of the co-administered medicines.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 28 (5), 841-844, 2005
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679603548800
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- NII論文ID
- 10016663278
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- NII書誌ID
- AA10885497
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- COI
- 1:CAS:528:DC%2BD2MXlvVWit7o%3D
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 7304614
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- PubMed
- 15863890
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可