The Role of Dihydropyrazines in Accelerated Death of Escherichia coli on Addition of Copper(II)

• Takeda Osamu

  Department of Hygiene, Miyazaki Medical College Department of Public Health, Miyazaki Medical College

• Takechi Shinji

  Department of Hygiene, Miyazaki Medical College

• Katoh Takahiko

  Department of Public Health, Miyazaki Medical College

• Yamaguchi Tadatoshi

  Department of Hygiene, Miyazaki Medical College

Bibliographic Information

Other Title

• Role of Dihydropyrazines in Accelerated Death of Escherichia coli on Addition of Copper 2

Abstract

Dihydropyrazines (DHPs), which are derived from sugars, inhibit the growth of Escherichia coli. Addition of copper(II) ion (Cu²⁺) accelerates the effect of DHPs, resulting in cell death. Investigation of the lethal effect in several DNA repair-deficient or detoxifying enzyme-deficient mutant strains and radical scavengers suggested that the cytotoxic and genotoxic damage was caused by radical species (hydroxyl, superoxide anion, and carbon-centered radicals) generated from reaction of DHPs with Cu²⁺.

Journal

• Biological and Pharmaceutical Bulletin

  Biological and Pharmaceutical Bulletin 28 (7), 1161-1164, 2005

  The Pharmaceutical Society of Japan

Keywords

• dihydropyrazine
• DNA damage
• carbon-centered radical
• hydroxyl radical
• superoxide anion

Details

• CRID: 1390282679604300544
• NII Article ID: 10016664984
• NII Book ID: AA10885497
• DOI: 10.1248/bpb.28.1161
• COI: 1:CAS:528:DC%2BD2MXpsFaiu7w%3D
• ISSN: 13475215
• ISSN: 09186158
• NDL BIB ID: 7343320
• PubMed: 15997090
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7343320
• Web Site: http://www.jstage.jst.go.jp/article/bpb/28/7/28_7_1161/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2006247764
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed