The Role of Dihydropyrazines in Accelerated Death of Escherichia coli on Addition of Copper (II)(Molecular and Cell Biology)

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Dihydropyrazines (DHPs), which are derived from sugars, inhibit the growth of Escherichia coli. Addition of copper (II) ion (Cu^<2+>) accelerates the effect of DHPs, resulting in cell death. Investigation of the lethal effect in several DNA repair-deficient or detoxifying enzyme-deficient mutant strains and radical scavengers suggested that the cytotoxic and genotoxic damage was caused by radical species (hydroxyl, superoxide anion, and carboncentered radicals) generated from reaction of DHPs with Cu^<2+>.

収録刊行物

  • Biological & pharmaceutical bulletin

    Biological & pharmaceutical bulletin 28(7), 1161-1164, 2005-07-01

    公益社団法人日本薬学会

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被引用文献:  5件中 1-5件 を表示

各種コード

  • NII論文ID(NAID)
    10016664984
  • NII書誌ID(NCID)
    AA10885497
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09186158
  • NDL 記事登録ID
    7343320
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-V41
  • データ提供元
    CJP書誌  CJP引用  NDL  NII-ELS  J-STAGE 
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