Gd-EOB-DTPA Enhanced MRI for Hepatocellular Carcinoma: Quantitative Evaluation of Tumor Enhancement in Hepatobiliary Phase

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  • SAITO Kazuhiro
    Department of Radiology, Tokyo Medical University Kasumigaura Hospital
  • KOTAKE Fumio
    Department of Radiology, Tokyo Medical University Kasumigaura Hospital
  • ITO Naoki
    Department of Radiology, Tokyo Medical University
  • OZUKI Taizo
    Department of Radiology, Tokyo Medical University
  • MIKAMI Ryuji
    Department of Radiology, Tokyo Medical University Kasumigaura Hospital
  • ABE Kimihiko
    Department of Radiology, Tokyo Medical University
  • SHIMAZAKI Yoko
    Department of Radiology, Tokyo Medical University

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Objective: The purpose of this study was to evaluate the utility of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) for the quantitative evaluation of hepatocellular carcinoma (HCC) and dysplastic nodules in the hepatobiliary phase.<br> Material and Methods: The subjects comprised 12 patients with 27 lesions (22 HCCs and 5 dysplastic nodules). Chemical-shift-selective fat-suppressed T1-weighted sequences were obtained before and 10, 20, and 40 min after the injection of Gd-EOB-DTPA. Quantitative analyses were performed with the enhancement ratio of the lesion and the contrast-to-noise (C/N) ratio.<br> Results: The enhancement ratios of the HCCs were 44.0±36.5, 44.7±46.8, and 47.7±52.8 (%) at 10, 20, and 40 min, respectively, after the injection of Gd-EOB-DTPA. The enhancement ratios of the dysplastic nodules were 36.2±34.3, 44.3±37.3, and 40.1±46.8 (%). The C/N ratios of the HCCs were 0.2±6.6 for the precontrast image, and -9.2±12.6, -9.9±14.8, and -12.7±15.7 at 10, 20, and 40 min, respectively, after the injection of Gd-EOB-DTPA. The C/N ratios of the dysplastic nodules were 1.4±8.0, -13.7±11.1, -13.3±7.6, and -13.1±10.4. No significant differences were found between the HCCs and the dysplastic nodules in the enhancement ratio and the C/N ratio. Only two HCCs showed a positive C/N ratio value, and these HCCs were pathologically confirmed to be a well differentiated and a moderately differentiated carcinoma, respectively.<br> Conclusion: HCCs and some of the dysplastic nodules showed hypointensity in the hepatobiliary phase in Gd-EOB-DTPA-enhanced MRI. No specific enhancement was observed, regardless of tumor differentiation.<br>

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