Effect of Combined Vitamin E and Insulin Administration on Renal Damage in Diabetic Rats Fed a High Cholesterol Diet
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- Yoshida Masumi
- Pharmacology Division, Nihon Bioresearch Inc.
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- Kimura Hitoshi
- Pharmacology Division, Nihon Bioresearch Inc.
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- Kyuki Kouhei
- Pharmacology Division, Nihon Bioresearch Inc.
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- Ito Mikio
- Laboratory of Analytical Pharmacology, Faculty of Pharmacy, Meijo University
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In the present study, we investigated the effects of a long-term treatment with vitamin E, an antioxidant vitamin, insulin, or their combination on renal damage in streptozotocin (STZ)-induced diabetic rats fed a high cholesterol diet. Increases in urinary albumin and lipid peroxide (LPO) excretions were observed in these diabetic rats, when both urinary parameters were measured at 8 and 15 weeks after STZ administration. Daily treatment with vitamin E, insulin, or their combination markedly suppressed the increase in the 24 h urinary albumin and lipid peroxide excretions. Furthermore, glycogen degeneration of distal tubules, fatty degeneration of glomerular endothelium and hypertrophy of glomeruli and mesangium were observed in the kidneys of the diabetic animals when histopathological evaluation was performed at 4, 8, and 15 weeks (glomerular and mesangial hypertrophy were observed only at 15 weeks). Combined vitamin E and insulin treatment was the most effective at suppressing these renal histopathological changes. These results indicate that combined vitamin E and insulin treatment additively prevents the development and progression of renal damage in diabetic rats. Possible mechanisms for the preventive effect of this combined treatment are discussed.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 28 (11), 2080-2086, 2005
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204626680448
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- NII論文ID
- 10016783455
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 7675602
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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