Insights into the Biological Redox Chemistry of 2'-Deoxyadenosine 5'-Monophosphate by Electrochemical Techniques

• Rajendra N. Goyal

• Aikta Dhawan

書誌事項

タイトル別名

• Insights into the Biological Redox Chemistry of 2 Deoxyadenosine 5 Monophosphate by Electrochemical Techniques

抄録

The electrochemical oxidation of 2′-deoxyadenosine 5′-monophosphate at a pyrolytic graphite electrode (PGE) was studied in the pH range 2.65–10.03 and was found to proceed in a single well-defined oxidation peak, Ia, over the entire pH range. The cyclic voltammetric behavior indicated the pH dependence of the oxidation pathway. The kinetic studies of the UV-absorbing intermediate generated during electrooxidation were followed spectrophotometrically, and decay occurred in a pseudo first-order reaction having k values in the range (0.595–0.986) × 10−3 s−1 over the entire pH range studied. Coulometric studies indicated that the process of the oxidative pathway involved n values as 5.0 ± 0.5 in the acidic range (pH 3.37) and 4.0 ± 0.5 at physiological pH 7.22. The products of electrooxidation were characterized by GC-MS and on the basis of electrochemical, spectrochemical, and product analysis; a plausible redox mechanism is suggested.

収録刊行物

• Bulletin of the Chemical Society of Japan

  Bulletin of the Chemical Society of Japan 78 (11), 1944-1952, 2005

  Tokyo : Chemical Society of Japan

キーワード

• General Chemistry

詳細情報

• CRID: 1521417753463518592
• NII論文ID: 10016844957
• NII書誌ID: AA00580132
• ISSN: 00092673
• ISSN: 13480634
• DOI: 10.1246/bcsj.78.1944
• NDL書誌ID: 7695596
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7695596
• Web Site: https://academic.oup.com/bcsj/article-pdf/78/11/1944/56266752/bcsj.78.1944.pdf
• 本文言語コード: en
• NDL 雑誌分類:
  • ZP1(科学技術--化学・化学工業)
• データソース種別:
  • NDL
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