Three-Dimensional Structure of 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase from Human Brain

• SAKAMOTO Yasumitsu

  School of Nursing and Rehabilitation Sciences, Showa University

• TANAKA Nobutada

  School of Pharmaceutical Sciences, Showa University

• NAKAMURA Kazuo T.

  School of Pharmaceutical Sciences, Showa University

Bibliographic Information

Other Title

• ヒト脳膜結合型環状化ヌクレオチドホスホジエステラーゼの立体構造と反応機構
• サイキン ノ ケンキュウ カラ ヒト ノウマク ケツゴウガタ カンジョウカ ヌクレオチドホスホジエステラーゼ ノ リッタイ コウゾウ ト ハンノウ キコウ

Abstract

2', 3'-cyclic nucleotide 3'-phosphodiesterase (CNP), a member of the 2H phosphoesterase superfamily, is found mainly in the central nervous system (CNS) of vertebrates, and it catalyzes the hydrolysis of 2', 3'-cyclic nucleotide to produce 2'-nucleotidein vitro. Recent studies on CNP-knockout mice have revealed that the absence of CNP causes axonal swelling and neuronal degeneration. Here we report crystal structure of the catalytic fragment of human CNP (hCNP-CF) at 1.8Å resolution.

Journal

• Nihon Kessho Gakkaishi

  Nihon Kessho Gakkaishi 47 (6), 403-408, 2005

  The Crystallographic Society of Japan

Details

• CRID: 1390282679063322240
• NII Article ID: 10016908537
• NII Book ID: AN00188364
• DOI: 10.5940/jcrsj.47.403
• ISSN: 18845576
• ISSN: 03694585
• NDL BIB ID: 7786207
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7786207
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed