The Roles of Cytokines, Inflammation and Immunity in Vascular Diseases

• Ohsuzu Fumitaka

  The First Department of Medicine, National Defense Medical College, Saitama, Japan

抄録

Recent findings regarding the roles of cytokines, inflammation and immunity during the development of atherosclerosis were reviewed. Especially, the relationships among pro-inflammatory cytokines such as interleukin (IL)-1, IL-18 and osteopontin, and anti-inflammatory cytokines such as IL-1 receptor antagonist, IL-10 and IL-18 binding protein to inflammation and atherosclerosis were investigated and are described in detail. In addition, helicobacter pylori and C pneumoniae infections to inflammations regarding the persistence of inflammation have been pointed out. A pro-inflammatory genotype or haplotype and toll-like receptors have been shown to be involved in human atherosclerosis. Atherosclerosis might therefore be a specific form of the chronic inflammatory process. In addition to hyperlipidemia, infections, cytokines and immunity might also be involved in the development of atherosclerosis. Certain treatments that reduce coronary risk also limit inflammation. Statins possess multiple pleiotropic effects such as an anti-inflammatory effect in addition to a lipid-lowering effect.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ

  Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ 11 (6), 313-321, 2004

  一般社団法人 日本動脈硬化学会

キーワード

• Cytokine
• Inflammation
• Toll-like
• receptor
• Immunity
• Atherosclerosis

詳細情報

• CRID: 1390282679408053760
• NII論文ID: 130004444117
• NII論文ID: 10016994786
• NII書誌ID: AA11018976
• DOI: 10.5551/jat.11.313
• COI: 1:CAS:528:DC%2BD2MXhsVehsr4%3D
• ISSN: 18803873
• ISSN: 13403478
• ISSN: http://id.crossref.org/issn/13403478
• PubMed: 15644584
• Web Site: https://www.jstage.jst.go.jp/article/jat/11/6/11_6_313/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2005202104
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可