成人Ｔ細胞白血病（ＡＴＬ）患者の皮膚病変に対する治療法の比較検討

• 片平 充彦

  鹿児島大学皮膚科学教室

• 田中 昭人

  鹿児島大学皮膚科学教室

• 瀬戸山 充

  鹿児島大学皮膚科学教室

• 神崎 保

  鹿児島大学皮膚科学教室

書誌事項

タイトル別名

• Comparative examination of therapy for skin lesion of adult T cell leukemia (ATL) patient.

抄録

We studied and compared the effects of chemotherapy, radiotherapy, ultraviolet irradiation therapy (PUVA therapy), therapy with biological response modifiers (BRM) and other therapies for the skin lesions in 22 patients with adult T-cell leukemia (ATL), April 1994 trough July 1997.<br>Patients with a complete response (CR) or partial response (PR) were 15 out of 23 (65%) for chemotherapy, 5/5 (100%) for radiotherapy, 11/13 (85%) for ultraviolet irradiation therapy, 5/7 (71%) for BRM, and 7/21 (33%) for other therapies. All therapies except “other therapies” showed high response rates. The response rate was lower in recurrent skin lesions with chemotherapy. Patients with complete responses after radiotherapy developed leukemia possibly due to a decrease in immunological competence caused by radiotherapy. On the other hand, a good response was seen in recurrent foci with PUVA therapy. BRM therapy did not cause drug tolerance in the lesions or any serious adverse reactions.

収録刊行物

• Ｓｋｉｎ　Ｃａｎｃｅｒ

  Ｓｋｉｎ　Ｃａｎｃｅｒ 13 (1), 66-71, 1998

  日本皮膚悪性腫瘍学会

キーワード

• ATL (Adult T-cell leukemia)
• Treatment
• Responsiveness
• Skin lesion

詳細情報

• CRID: 1390282679313759232
• NII論文ID: 10017219005
• NII書誌ID: AN10087647
• DOI: 10.5227/skincancer.13.66
• ISSN: 18843549
• ISSN: 09153535
• ISSN: http://id.crossref.org/issn/09153535
• Web Site: https://search.jamas.or.jp/link/ui/1998257737
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可