生理活性物質の全合成とその実践的展開の重要性

• 竜田 邦明

  早稲田大学大学院理工学研究科

書誌事項

タイトル別名

• Total Syntheses of Useful Bioactive Compounds and Significance of their Developments
• セイリ カッセイ ブッシツ ノ ゼンゴウセイ ト ソノ ジッセンテキ テンカイ ノ ジュウヨウセイ

抄録

Herein are described the first total syntheses of some bioactive compounds, which have been accomplished in my laboratories by a variety of strategies and methodologies to clarify their structure-activity relationships and to create practically useful lead compounds for new medicines. The target molecules are antibiotics (tylosin, oleandomycin and tetracycline), antifungals (nanaomycin D and kalafungin), antitumors (lymphostin and BE-54238 B), glycosidase inhibitors (cyclophellitol and nagstatin), peptidase inhibitors (pyrizinostatin, antipain and chymostatin), nervous systemaffecting products (deacetyl-caloporoside, calbistrin A and ES-242-4), mussel-attachment inhibitors (sideroxylonal B and C), anti-pylori (PC-3 and YM-30059), TPO receptor agonist (xanthocillin X dimethylether), and so on.

収録刊行物

• 有機合成化学協会誌

  有機合成化学協会誌 64 (5), 458-470, 2006

  公益社団法人 有機合成化学協会

キーワード

• total synthesis
• natural products
• bioactivities
• structure-activity relationships
• mode of action

詳細情報

• CRID: 1390282680289459200
• NII論文ID: 10017486563
• NII書誌ID: AN0024521X
• DOI: 10.5059/yukigoseikyokaishi.64.458
• ISSN: 18836526
• ISSN: 00379980
• NDL書誌ID: 7959935
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7959935
• 本文言語コード: ja
• データソース種別:
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  • NDL
  • Crossref
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  • KAKEN
• 抄録ライセンスフラグ: 使用不可