任意の症例構成比率を確保するための動的割付

• 西 次男

  株式会社ベルシステム 24医薬関連ビジネスユニット

書誌事項

タイトル別名

• A Dynamic Allocation Procedure to Enable to Achieve a Specific Proportion of Sample Sizes
• ニンイ ノ ショウレイ コウセイ ヒリツ オ カクホ スル タメ ノ ドウテキ ワリツケ

抄録

We showed a dynamic allocation procedure to achieve a specified proportion of sample sizes among treatment groups not only within all patients, but also within patients with strata composed of centers and/or prognostic factors in randomized controlled clinical trials. This procedure allocates a patient to one of treatment groups that are within a pre-specified range from the best balance, as well as the treatment groups with the best balance. When target sample sizes of two treatment groups are the same, Zelen (1974) showed a restriction for a range of obtained sample sizes. Proposed method is an extension of Zelen's restriction to the case of different target sample sizes of more than two treatment groups. This method can introduce randomness into a dynamic allocation procedure keeping comparability among treatment groups.

収録刊行物

• 計量生物学

  計量生物学 27 (1), 69-79, 2006

  日本計量生物学会

キーワード

• dynamic allocation
• minimization
• randomized controlled trial
• different sample size

詳細情報

• CRID: 1390282679347458944
• NII論文ID: 10018012993
• NII書誌ID: AA11591618
• DOI: 10.5691/jjb.27.69
• ISSN: 21856494
• ISSN: 09184430
• NDL書誌ID: 8007749
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8007749
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可