イマチニブで完全奏効した空腸ｇａｓｔｒｏｉｎｔｅｓｔｉｎａｌ　ｓｔｒｏｍａｌ　ｔｕｍｏｒ肝転移の１例

DOI Web Site 参考文献10件

書誌事項

タイトル別名
  • A COMPLETE RESPONSE TO IMATINIB MESYLATE IN A PATIENT WITH MULTILE LIVER METASTASES OF A JEJUNAL GASTROINTESTINAL STROMAL TUMOR

この論文をさがす

抄録

A 70-year-old man was found to have multiple liver tumors on ultrasonographic examination for abdominal pain and fever, and was introduced to our hospital for further evaluation and treatment. Additional examinations revealed multiple liver metastases of a jejunal submucosal tumor. Surgery was performed in December 2004, and multiple solid tumors in the liver and a mass of 5cm in diameter at the beginning of the jejunum were found. Partial resection of the jejunum was performed to remove the main jejunal tumor. Histopathological findings revealed fascicular proliferation of spindle-shaped cells in the tumor. Innunohistochemical findings demonstrated that the tumor cells were positive for c-kit, and negative for SMA and S-100. The pathological diagnosis was gastrointestinal stromal tumor (GIST). The patient was given imatinib mesylate at a dose of 400mg/day to treat liver metastases. CT scans and ultrasonographic examination obtained three and a half months after the treatment with imatinib mesylate showed that the hepatic metastatic lesions had disappeared. There are no further signs of recurrence as of 7 months after the drug regimen. Complete response of GIST to imatinib mesylate is rare. We report this patient with liver metastasis of jejunal GIST which responded to the medication completely after the resection of the jejunal tumor.

収録刊行物

参考文献 (10)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ