A CASE OF DUODENAL GIST WHICH WAS FOLLOWED UP THE PROGRESS WITH IMATINIB MESILETE BY ENDOSCOPY

  • ODA Sai
    Division of Gastroenterology and Ilepatology, Department of Internal Medicine, The Jikei University School of Medicine
  • ISHIKAWA Tomohisa
    Division of Gastroenterology and Ilepatology, Department of Internal Medicine, The Jikei University School of Medicine
  • SAITO Masaya
    Division of Gastroenterology and Ilepatology, Department of Internal Medicine, The Jikei University School of Medicine
  • TORISU Yuichi
    Division of Gastroenterology and Ilepatology, Department of Internal Medicine, The Jikei University School of Medicine
  • ISHII Hironori
    Division of Gastroenterology and Ilepatology, Department of Internal Medicine, The Jikei University School of Medicine
  • TAKAHASHI Hiroki
    Division of Gastroenterology and Ilepatology, Department of Internal Medicine, The Jikei University School of Medicine
  • HOKARI Atsushi
    Division of Gastroenterology and Ilepatology, Department of Internal Medicine, The Jikei University School of Medicine
  • KOIKE Kazuhiko
    Division of Gastroenterology and Ilepatology, Department of Internal Medicine, The Jikei University School of Medicine
  • TORII Akira
    Division of Gastroenterology and Ilepatology, Department of Internal Medicine, The Jikei University School of Medicine
  • ZENIYA Mikio
    Division of Gastroenterology and Ilepatology, Department of Internal Medicine, The Jikei University School of Medicine
  • TAJIRI Hisao
    Division of Gastroenterology and Ilepatology, Department of Internal Medicine, The Jikei University School of Medicine

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Other Title
  • メシル酸イマチニブによる治療経過が内視鏡的に観察された十二指腸GISTの1例

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Abstract

A 68-year-old man presented with tarry stool and anemia. We found sub mucosal tumor (SMT) at the oral side of 2nd portion in the duodenum by endoscope and imaging studies. The SMT was 3cm in diameter with central ulceration, where smoldering hemorrhage was noted. Histological examination showed spindle tumor cells that expressed CD 117 by immunohistochemical studies. We diagnosed this SMT as GIST of the duodenum. When he admitted hospital, the tumor was unresectable because of multiple huge liver metastases. We selected treatment with imatinib mesylate. The remarkable tumor reduction was confirmed with CT and endoscope after treatment. The SMT in the duodenum vanished in 10 month after.

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