口腔扁平上皮癌の浸潤先進部における脈管密度の検討―特に癌浸潤様式に伴う血管密度とリンパ管密度の推移の比較―

  • 中谷 弘光
    市立敦賀病院歯科口腔外科
  • 川尻 秀一
    金沢大学大学院医学系研究科がん医科学専攻がん細胞学講座細胞浸潤学分野
  • 田中 彰
    金沢大学大学院医学系研究科がん医科学専攻がん細胞学講座細胞浸潤学分野
  • 能崎 晋一
    金沢大学大学院医学系研究科がん医科学専攻がん細胞学講座細胞浸潤学分野
  • 野口 夏代
    金沢大学大学院医学系研究科がん医科学専攻がん細胞学講座細胞浸潤学分野
  • 加藤 広禄
    金沢大学大学院医学系研究科がん医科学専攻がん細胞学講座細胞浸潤学分野
  • 長谷 剛志
    金沢大学大学院医学系研究科がん医科学専攻がん細胞学講座細胞浸潤学分野
  • 中川 清昌
    金沢大学大学院医学系研究科がん医科学専攻がん細胞学講座細胞浸潤学分野
  • 立川 哲彦
    昭和大学歯学部口腔病理学教室
  • 山本 悦秀
    金沢大学大学院医学系研究科がん医科学専攻がん細胞学講座細胞浸潤学分野

書誌事項

タイトル別名
  • Studies on vessel densities at invasive front of oral squamous cell carcinoma, with special reference to comparison between blood and lymph vessel densities according to mode of cancer invasion
  • with special reference to comparison between blood and lymph vessel densities according to mode of cancer invasion
  • ―特に癌浸潤様式に伴う血管密度とリンパ管密度の推移の比較―

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抄録

Regional lymph node metastasis is closely related to the prognosis of squamous cell carcinoma of the oral cavity, and control of lymph node metastasis is an important therapeutic strategy. Therefore, microlymphatic movement is of concern in the primary lesion. However, there are many ambiguous points in that it can be difficult to distinguish between blood vessels and lymph vessels. This study was conducted in order to clarify the various relationships among angiogenesis, lymphangiogenesis, and tumor invasion in cancers of the oral cavity. Using a double stain of 5'-nucleotidase-alkaline phosphatase, blood and lymph vessel densities were measured simultaneously. Thereafter, the relationship between clinicopathological factors and blood and lymph vessel densities was investigated.<BR>Results: 1) Blood and lymph vessel densities in normal mucosal epithelium were 27.4±4.4 and 12.8±4.0, respectively. On the other hand, those of cancer cases were 9.5±6.3 and 6.4±1.7, respectively. 2) Among the clinicopathological factors, T category, N category and grade of tumor differentiation did not correlate with blood and lymph vessel densities in metastatic or moderately to poorly differentiated cases. On the other hand, regarding the mode of invasion, the more diffuse the mode of invasion the higher the blood vessel density. However, the lymph vessel density was generally similar in each grade of mode of invasion with a slight increase in highly invasive carcinoma.

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