書誌事項
- タイトル別名
-
- Efficacy, safety, and pharmacokinetics of cefcapene pivoxil in children
この論文をさがす
抄録
An oral cephalosporin antibiotic, cefcapene pivoxil (CFPN-PI), was administered to 128 pediatric patients in a multi-centered post-marketing clinical trial, and its pharmacokinetics efficacy, and safety were investigated. The results obtained are described below.<BR>1. Population Pharmacokinetics<BR>CL/F and Vd/F were in proportion to body weight, and there were no differences in pharmacokinetic data between patients under 10kg and patients over 10kg (110 evaluated patients).<BR>2. Efficacy<BR>The efficacy rate against respiratory infections and urology infections were very high (88.1% and 100%, respectively).<BR>3. Bacteriological Efficacy<BR>CFPN-PI displayed potent antibacterial activity against various bacteria, including Penicillin-resistant Streptococcus pneumoniae (PRSP).<BR>4. Safety<BR>Adverse drug reactions manifested as clinical symptoms were observed in 18 of the 128 cases (18 events). All events except 1 rash consisted of gastrointestinal symptoms. Adverse drug reactions in the form of abnormal laboratory test values were observed in 11 of 116 cases (15 events), including 4 cases each AST elevation and ALT elevation.<BR>The above results, confirmed that CFPN-PI is efficacious, safe and yields favorable pharmacokinetic data when administered to pediatric patients, including infants (except for newborns), at the approved dosage and administration method.
収録刊行物
-
- 日本化学療法学会雑誌
-
日本化学療法学会雑誌 54 (5), 465-477, 2006
公益社団法人 日本化学療法学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390282681262421760
-
- NII論文ID
- 130004298306
- 10018041011
-
- NII書誌ID
- AN10472127
-
- ISSN
- 18845886
- 13407007
-
- 本文言語コード
- ja
-
- データソース種別
-
- JaLC
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可
