Polycystic Ovary Syndrome and Hepatocellular Adenoma Related to Long-Term Use of Sodium Valproate in a Young Woman

DOI PubMed 1 Citations 20 References
  • Seki Ayumi
    Division of Child Neurology, Faculty of Medicine, Tottori University
  • Inoue Takehiko
    Division of Child Neurology, Faculty of Medicine, Tottori University
  • Maegaki Yoshihiro
    Division of Child Neurology, Faculty of Medicine, Tottori University
  • Sugiura Chitose
    Division of Child Neurology, Faculty of Medicine, Tottori University
  • Toyoshima Mitsuo
    Department of Pediatrics, Tottori Prefectural Central Hospital
  • Akaboshi Shinjiro
    Department of Pediatrics, National Hospital Organization Tottori Medical Center
  • Ohno Kousaku
    Division of Child Neurology, Faculty of Medicine, Tottori University

Bibliographic Information

Other Title
  • Ｖａｌｐｒｏａｔｅ　ｓｏｄｉｕｍ長期服用中に多嚢胞卵巣症候群と肝細胞腺腫を生じた女性例

Search this article

Abstract

Previous studies have reported a high prevalence of polycystic ovary syndrome (PCOS) among women taking sodiumvalproate (VPA). We report the case of a 28 year-old epileptic female taking VPA, who developed PCOS and later hepatocellular adenoma. She had been taking VPA for intractable epilepsy since the age of 15 months. At the age of 22 years, she suffered spontaneous rupture of a liver tumor that was diagnosed as hepatocellular adenoma. At the age of 24 years, bilateral polycystic ovaries were found by transabdominal ultrasonography, and PCOS was diagnosed. VPA may directly influence steroidogenesis in the ovary and cause hyperandrogenemia with ensuing PCOS. It is known that abnormality in the sex hormones contributes to the onset of hepatocellular adenoma. Therefore, we speculate that hyperandrogenemia due to VPA contributed to the development of hepatocellular adenoma in this case

Journal

  • NO TO HATATSU

    NO TO HATATSU 38 (3), 205-208, 2006

    THE JAPANESE SOCIETY OF CHILD NEUROLOGY

Citations (1)*help

See more

References(20)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top