ヒトにおける前庭-視覚矛盾刺激により得られる前庭動眼反射(VOR)適応現象の角速度特異性について Flexibility of Adaptation of Vestibule-ocular Reflex in Human Beings

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著者

    • 鈴木 一輝 SUZUKI Kazuteru
    • 聖マリアンナ医科大学耳鼻咽喉科学教室 Department of Otolaryngology, St. Marianna University School of Medicine
    • 渡辺 昭司 WATANABE Shoji
    • 聖マリアンナ医科大学耳鼻咽喉科学教室 Department of Otolaryngology, St. Marianna University School of Medicine
    • 島田 園子 SHIMADA Sonoko
    • 聖マリアンナ医科大学耳鼻咽喉科学教室 Department of Otolaryngology, St. Marianna University School of Medicine
    • 肥塚 泉 KOIZUKA Izumi
    • 聖マリアンナ医科大学耳鼻咽喉科学教室 Department of Otolaryngology, St. Marianna University School of Medicine

抄録

前庭動眼反射には長時間続く視覚入力の変化に対しその特性を変化させ,頭部運動時に指標の網膜上のずれを防ぐ機構があり,これを適応現象という.今回我々は19名の健康成人を対象とし,2種類の視覚-前庭矛盾による適応刺激(30度/秒,60度/秒)を与え,他の条件への移行様式に違いがあるか検討を加えた.また回転軸が変化した場合に,獲得した適応現象がどのような影響を受けるかを検討する為,EVA(earth vertical rotation)下に60度秒で適応現象を獲得した後,どのような適応現象の移行を示すかを30度nose-up•30度nose-downでのOVAR(off vertical axis rotation)下で検討した.適応刺激には網膜上の視機刺激のずれ速度を2倍にする方法(×2刺激)と,なくす方法(×0刺激)を用いた,最大角速度30度/秒,周波数0.3Hzでは×2刺激で30度/秒と40度/秒で利得増加を認め,より大きな角速度への適応現象の移行を認めた.最大角速度60度/秒,周波数0.3Hzでは×2刺激で他の角速度への移行はなかった.OVARでは×2刺激で利得増加を認めたが,×0刺激では利得変化は認めなかった.半規管-眼反射における適応現象は角速度の違いによる差異を有する可能性が示唆された.OVARでの利得の変化はこれを構成する成分である半規管-眼反射の変化によるものと思われた.

Vestibulo-ocular reflex (VOR) makes images remain relatively stable on the retina. To keep appropriate performance and minimize image slip throughout life, VOR is subject to long-term adaptive regulation by visual input. It has been reported that adaptive changes in VOR gain (eye velocity/head velocity) are evoked either by fitting subjects with magnifying, miniaturizing, or reversing spectacles during normal behavior or by moving a large visual field in or out of phase relative to the subject's head movement. These feature frequency-selectivity. We studied the flexibility of adaptive gain change in VOR required by a horizontal visual-vestibular mismatch in earth vertical axis rotation (EVAR), including adaptive gain change from EVA to off-vertical axis rotation (OVAR) and other velocities. The visual-vestibular mismatch was made by oscillating subjects in EVAR for 30 minutes at 0.3Hz with the peak velocity of 30 deg/s and 60 deg/s, synchronized with both in-phase (gain decrease: ×0 experiment) and out-of-phase (gain increase: ×2 experiment) sinusoidal rotation of white-black stripe patterns. Subjects were 19 healthy adult volunteers with no history of neurological symptoms. Horizontal and vertical eye positions were recorded by bitemporal DC-coupled electrooculography.<br>In the ×2 adaptation experiment with 0.3Hz at the peak velocity of 30 deg/s, the percent change in gain (post-pre/pre) was 110% at the same stimulation and 100% at 40 deg/s in EVA. In the ×0 adaptation experiment with 0.3Hz at the peak velocity of 30 deg/s, the percent change in gain was -50% at the same stimulation in EVA. In the ×2 adaptation experiment with 0.3Hz at the peak velocity of 60 deg/s, the percent change in gain was 66% at the same stimulation in EVA, 30% at the same stimulation in nose-up position, and 74% at the same stimulation in nose-down position. In the ×0 adaptation experiment with 0.3Hz at the peak velocity of 60 deg/s, the percent change in gain was -34% at the same stimulation in EVA No change in VOR gain was observed at other peak velocities.<br>These results suggest that VOR adaptation depends frequency and maximum angular head velocity, and this characteristic is observed in OVAR.

収録刊行物

  • 日本耳鼻咽喉科學會會報  

    日本耳鼻咽喉科學會會報 109(5), 461-468, 2006-05-20 

    The Oto-Rhino-Laryngological Society of Japan, Inc.

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各種コード

  • NII論文ID(NAID)
    10018059854
  • NII書誌ID(NCID)
    AN00191551
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    00306622
  • NDL 記事登録ID
    7976242
  • NDL 雑誌分類
    ZS43(科学技術--医学--耳鼻咽喉科学)
  • NDL 請求記号
    Z19-250
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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