Flexibility of Adaptation of Vestibule-ocular Reflex in Human Beings

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  • Suzuki Kazuteru
    Department of Otolaryngology, St. Marianna University School of Medicine
  • Watanabe Shoji
    Department of Otolaryngology, St. Marianna University School of Medicine Washington University School of Medicine, Anatomy and Neurobiology
  • Kato Yumiko
    Department of Otolaryngology, St. Marianna University School of Medicine
  • Shimada Sonoko
    Department of Otolaryngology, St. Marianna University School of Medicine
  • Koizuka Izumi
    Department of Otolaryngology, St. Marianna University School of Medicine

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Other Title
  • ヒトにおける前庭―視覚矛盾刺激により得られる前庭動眼反射（ＶＯＲ）適応現象の角速度特異性について
  • ヒト ニ オケル ゼンテイ シカク ムジュン シゲキ ニ ヨリ エラレル ゼンテイドウガン ハンシャ VOR テキオウ ゲンショウ ノ カクソクド トクイセイ ニ ツイテ
  • 視覚矛盾刺激により得られる前庭動眼反射(VOR)適応現象の角速度特異性について

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Abstract

Vestibulo-ocular reflex (VOR) makes images remain relatively stable on the retina. To keep appropriate performance and minimize image slip throughout life, VOR is subject to long-term adaptive regulation by visual input. It has been reported that adaptive changes in VOR gain (eye velocity/head velocity) are evoked either by fitting subjects with magnifying, miniaturizing, or reversing spectacles during normal behavior or by moving a large visual field in or out of phase relative to the subject's head movement. These feature frequency-selectivity. We studied the flexibility of adaptive gain change in VOR required by a horizontal visual-vestibular mismatch in earth vertical axis rotation (EVAR), including adaptive gain change from EVA to off-vertical axis rotation (OVAR) and other velocities. The visual-vestibular mismatch was made by oscillating subjects in EVAR for 30 minutes at 0.3Hz with the peak velocity of 30 deg/s and 60 deg/s, synchronized with both in-phase (gain decrease: ×0 experiment) and out-of-phase (gain increase: ×2 experiment) sinusoidal rotation of white-black stripe patterns. Subjects were 19 healthy adult volunteers with no history of neurological symptoms. Horizontal and vertical eye positions were recorded by bitemporal DC-coupled electrooculography.<br>In the ×2 adaptation experiment with 0.3Hz at the peak velocity of 30 deg/s, the percent change in gain (post-pre/pre) was 110% at the same stimulation and 100% at 40 deg/s in EVA. In the ×0 adaptation experiment with 0.3Hz at the peak velocity of 30 deg/s, the percent change in gain was -50% at the same stimulation in EVA. In the ×2 adaptation experiment with 0.3Hz at the peak velocity of 60 deg/s, the percent change in gain was 66% at the same stimulation in EVA, 30% at the same stimulation in nose-up position, and 74% at the same stimulation in nose-down position. In the ×0 adaptation experiment with 0.3Hz at the peak velocity of 60 deg/s, the percent change in gain was -34% at the same stimulation in EVA No change in VOR gain was observed at other peak velocities.<br>These results suggest that VOR adaptation depends frequency and maximum angular head velocity, and this characteristic is observed in OVAR.

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