Screening Method for Postprandial Hyperglycemia Using 1,5-Anhydroglucitol Combined with Fasting Plasma Glucose

  • Kanazawa Yuichi
    Foundation of Kinki Health Administration Center Shiga Department Clinic

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Other Title
  • 1,5-アンヒドログルシトール(1,5-AG)による食後高血糖のスクリーニング
  • 1,5-アンヒドログルシトール(1,5-AG)による食後高血糖のスクリーニング--空腹時血糖値の組み合わせ法
  • 1 5 アンヒドログルシトール 1 5 AG ニ ヨル ショク ゴ コウケットウ ノ スクリーニング クウフクジ ケットウチ ノ クミアワセ ホウ
  • —空腹時血糖値組み合わせ法—

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Abstract

It is extremely important in preventive medicine to screen for postprandial hyperglycemia (PPHG), which is considered to be a risk factor for diabetes and macroangiopathy. We devised a screening method in which gender-segregated cutoff values for 1,5-anhydroglucitol (1,5-AG) were set and the 1,5-AG level was combined with the fasting plasma glucose (FPG) level in cases that fell close to the 1,5-AG threshold. We called this method the KKC method. Using the KKC method, we obtained a sensitivity of 83.3% and a positive predictive value (PPV) of 71.4% when screening for PPHG. The screening results for FPG (using a 95 mg/dl cutoff value) were also 83.3% for sensitivity but had a much lower PPV. The KKC method appears to be an efficient screening method for PPHG during the fasting state. We have efficiently discovered 10-20 new subjects with PPHG every year in a community of 1,500 people using the KKC method.

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