Generalization of <I>Helicobacter pylori</I> Eradication Therapy and Its Future in Japan

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  • TAKAHASHI Shin'ichi
    The Third Department of Internal Medicine, Kyorin University School of Medicine
  • TOKUNAGA Kengo
    The Third Department of Internal Medicine, Kyorin University School of Medicine
  • TANAKA Akifumi
    The Third Department of Internal Medicine, Kyorin University School of Medicine

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Other Title
  • <I>Helicobacter pylori</I>除菌の一般化とその後の話題
  • Helicobacter pylori除菌の一般化とその後の話題
  • Helicobacter pyloriジョキン ノ イッパンカ ト ソノゴ ノ ワダイ
  • Generalization of Helicobacter pylori Eradication Therapy and Its Future in Japan

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Abstract

After official acceptance of eradication therapy for Helicobacter pylori infected peptic ulcer disease in 2000, this treatment has been generalized as ulcer therapy in Japan. In 2003 the consensus statement of the Japanese Society for Helicobacter Research (JSHR) for Helicobacter pylori infection was presented. According this statement MALT lymphoma was recommended to treat H. pylori infection because of the efficacy of its out come. Atrophic gastritis was also advised to treat H. pylori infection for the purpose of preventing gastric cancer development. The extra alimentary disease such as idiopathic thrombocytopenic purpura wasstill under evaluation.<BR>In diagnostic method the importance of drug susceptibility test is rising because of the increase of drug resistant H. pylori strain in Japan. The false positive case of urea breath test, the accuracy of new Japaneseoriginal serology tests and the stool antigen test are also under investigation.<BR>The standard regimen of H. pylori eradication therapy in Japan is proton pomp inhibitor (PPI) + amoxicilin (AMPC) + clarithromycin (CAM). The problem of this regimen is the decrease of eradication rate. The reason of this trend might be increase of CAM resistant strain. JSHR recommended a rescue regimen as PPI + AMPC + metronidazole for the patient whose first eradication therapy was unsuccessful result. The eradication of this second line regimen was reported as about 90%.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 80 (3), 203-211, 2006

    The Japanese Association for Infectious Diseases

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