Lewis Base-catalyzed Alkynylation of Carbonyl Compounds with Trimethylsilylacetylenes
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Alkynylation of carbonyl compounds with trimethylsilylacetylenes in the presence of a catalytic amount of Lewis bases such as acetate or phenoxide anion is described. The alkynylation proceeded under mild conditions and afforded the corresponding propargyl alcohols in good to excellent yields.
- Chemistry Letters
Chemistry Letters 35(9), 1002-1003, 2006-09-05
The Chemical Society of Japan