Synthesis and Biological Evaluation of Pyridooxazine–Tetrahydroisoquinoline Derivatives as MDR Modulators

• Ma Chen

  School of Chemistry and Chemical Engineering, Shandong University

• Liu Shao-Jie

  School of Chemistry and Chemical Engineering, Shandong University

• Xin Liang

  School of Chemistry and Chemical Engineering, Shandong University

• Zhang Qun

  School of Chemistry and Chemical Engineering, Shandong University

• Ding Kai

  School of Chemistry and Chemical Engineering, Shandong University

• Falck J. R.

  Department of Biochemistry, University of Texas Southwestern Medical Center

• Shin Dong-Soo

  Department of Chemistry, Changwon National University

抄録

Pyridooxazine–tetrahydroisoquinoline derivatives were designed and synthesized for MDR modulating activity. Pyridooxazin-2-one scaffolds were constructed in a one-pot annulation of N-substituted-2-chloroacetamides with 2-bromo-3-hydroxy pyridine via Smiles rearrangement. The Pictet–Spengler cyclization to form tetrahydroisoquinoline ring afforded target compounds in 17–37% overall yields. Some of these compounds exhibited multidrug resistance (MDR) reversing activity.

収録刊行物

• Chemistry Letters

  Chemistry Letters 35 (9), 1010-1011, 2006

  公益社団法人 日本化学会

キーワード

• General Chemistry

詳細情報

• CRID: 1390282679562747392
• NII論文ID: 10018062952
• NII書誌ID: AA00603318
• DOI: 10.1246/cl.2006.1010
• ISSN: 13480715
• ISSN: 03667022
• Web Site: https://academic.oup.com/chemlett/article-pdf/35/9/1010/55589105/cl.2006.1010.pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可