TRIFの polyproline track 鎖長の遺伝的多様性と HCV RNA clearance の相関 Atypical length of the TRIF polyproline track possibly associated with spontaneous clearance of HCV RNA

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We questioned whether there might be certain people who have TRIF that cannot be cut by HCV NS3/4A protease. Although the cleavage motif was invariably SSTPC/SAHLTPSSLE in all the 62 Japanese subjects examined, we found a genetic polymorphism at the polyproline track just upstream of the cleavage motif of TRIF: that is, the repeat number of proline was 8 in majority, but it was 6 or 9 in occasional subjects. Interestingly, the variant type TRIF (with 6 or 9 prolines) was found only in 13% (5/40) of those persistently infected with HCV, whereas it was found in 41% (9/22) of those who were positive for anti-HCV but negative for HCV RNA.<br>

収録刊行物

  • 肝臓 = ACTA HEPATOLOGICA JAPONICA  

    肝臓 = ACTA HEPATOLOGICA JAPONICA 47(6), 319, 2006-06-25 

    The Japan Society of Hepatology

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各種コード

  • NII論文ID(NAID)
    10018070480
  • NII書誌ID(NCID)
    AN00047770
  • 本文言語コード
    JPN
  • 資料種別
    SHO
  • ISSN
    04514203
  • データ提供元
    CJP書誌  J-STAGE 
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