C線維を上行する信号によって賦活される脳部位 : 機能的磁気共鳴画像(fMRI)を用いた研究 Cortical activities evoked by the signals ascending through unmyelinated C fibers in humans : a fMRI study

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著者

    • 柿木 隆介 KAKIGI Ryusuke
    • 総合研究大学院大学・生命科学研究科・生理科学専攻 Department of Physiological Sciences, School of Life Sciences, The Graduate University for Advanced Studies
    • 秋 云海 QIU Yunhai
    • 総合研究大学院大学・生命科学研究科・生理科学専攻 Department of Physiological Sciences, School of Life Sciences, The Graduate University for Advanced Studies
    • 野口 泰基 NOGUCHI Yasuki
    • 総合研究大学院大学・生命科学研究科・生理科学専攻 Department of Physiological Sciences, School of Life Sciences, The Graduate University for Advanced Studies
    • 本田 学 HONDA Manabu
    • 総合研究大学院大学・生命科学研究科・生理科学専攻 Department of Physiological Sciences, School of Life Sciences, The Graduate University for Advanced Studies
    • 中田 大貴 NAKATA Hiroki
    • 総合研究大学院大学・生命科学研究科・生理科学専攻 Department of Physiological Sciences, School of Life Sciences, The Graduate University for Advanced Studies
    • 田村 洋平 TAMURA Yohei
    • 総合研究大学院大学・生命科学研究科・生理科学専攻 Department of Physiological Sciences, School of Life Sciences, The Graduate University for Advanced Studies
    • 田中 悟志 TANAKA Satoshi
    • 総合研究大学院大学・生命科学研究科・生理科学専攻 Department of Physiological Sciences, School of Life Sciences, The Graduate University for Advanced Studies
    • 定藤 規弘 SADATO Norihiro
    • 総合研究大学院大学・生命科学研究科・生理科学専攻 Department of Physiological Sciences, School of Life Sciences, The Graduate University for Advanced Studies
    • 王 暁宏 WANG Xiaohong
    • 自然科学研究機構・生理学研究所統合生理研究系・感覚運動調節研究部門 Department of Integrative Physiology, National Institute for Physiological Sciences
    • 乾 幸二 INUI Koji
    • 総合研究大学院大学・生命科学研究科・生理科学専攻 Department of Physiological Sciences, School of Life Sciences, The Graduate University for Advanced Studies

抄録

   Acute pain is classified as first and second pain associated with rapidly conducting Aδ fibers and slowly conducting unmyelinated C fibers, respectively. First pain aims at achieving relative safety from the source of injury, whereas second pain, with its strong affective component, attracts longer-lasting attention and initiates behavioral responses in order to limit further injury and optimize recovery. Accordingly, the distinct brain representations for first and second pain should reflect distinct biological functions of both sensations.<br>   In this study, therefore, an event-related functional magnetic resonance imaging (fMRI) was used to investigate brain processing of the signals ascending from peripheral C and Aδ fibers evoked by phasic laser stimuli on the right hand in humans. The stimulation of both C and Aδ nociceptors activated the bilateral thalamus, bilateral secondary somatosensory cortex (SII), right (ipsilateral) middle insula, and bilateral Brodmanns area (BA) 24/32, with the majority of activity found in the posterior portion of the anterior cingulate cortex (pACC). However, magnitude of activity in the right (ipsilateral) BA32/8/6, including dorsal parts in the anterior portion of the ACC (aACC) and pre-supplementary motor area (pre-SMA), and the bilateral anterior insula was significantly stronger following the stimulation of C nociceptors than Aδ nociceptors. It was concluded that the activation of C nociceptors, related to second pain, evokes different brain processing from that of Aδ nociceptors, related to first pain, probably due to the differences in the emotional and motivational aspects of either pain, which are mainly related to the aACC, pre-SMA and anterior insula.

収録刊行物

  • Pain research : the journal of the Japanese Society for the Study of Pain = 日本疼痛学会誌  

    Pain research : the journal of the Japanese Society for the Study of Pain = 日本疼痛学会誌 21(3), 95-102, 2006-08-20 

    日本疼痛学会

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各種コード

  • NII論文ID(NAID)
    10018071456
  • NII書誌ID(NCID)
    AN10195934
  • 本文言語コード
    JPN
  • 資料種別
    REV
  • ISSN
    09158588
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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