<b>Cortical activities evoked by the signals ascending through </b><b>unmyelinated C fibers in humans: a fMRI study </b>

• Kakigi Ryusuke

  Department of Integrative Physiology, National Institute for Physiological Sciences Department of Physiological Sciences, School of Life Sciences, The Graduate University for Advanced Studies RISTEX, SORST, Japan Science and Technology Corp Agency (JST)

• Qiu Yunhai

  Department of Integrative Physiology, National Institute for Physiological Sciences Department of Physiological Sciences, School of Life Sciences, The Graduate University for Advanced Studies

• Noguchi Yasuki

  Department of Integrative Physiology, National Institute for Physiological Sciences Department of Physiological Sciences, School of Life Sciences, The Graduate University for Advanced Studies

• Honda Manabu

  Divison of Cerebral Integration, National Institute for Physiological Sciences Department of Physiological Sciences, School of Life Sciences, The Graduate University for Advanced Studies RISTEX, SORST, Japan Science and Technology Corp Agency (JST)

• Nakata Hiroki

  Department of Integrative Physiology, National Institute for Physiological Sciences Department of Physiological Sciences, School of Life Sciences, The Graduate University for Advanced Studies

• Tamura Yohei

  Department of Integrative Physiology, National Institute for Physiological Sciences Department of Physiological Sciences, School of Life Sciences, The Graduate University for Advanced Studies

• Tanaka Satoshi

  Divison of Cerebral Integration, National Institute for Physiological Sciences Department of Physiological Sciences, School of Life Sciences, The Graduate University for Advanced Studies

• Sadato Norihiro

  Divison of Cerebral Integration, National Institute for Physiological Sciences Department of Physiological Sciences, School of Life Sciences, The Graduate University for Advanced Studies RISTEX, SORST, Japan Science and Technology Corp Agency (JST)

• Wang Xiaohong

  Department of Integrative Physiology, National Institute for Physiological Sciences

• Inui Koji

  Department of Integrative Physiology, National Institute for Physiological Sciences Department of Physiological Sciences, School of Life Sciences, The Graduate University for Advanced Studies

Bibliographic Information

Other Title

• C 線維を上行する信号によって賦活される脳部位：機能的磁気共鳴画像（fMRI）を用いた研究

Abstract

   Acute pain is classified as first and second pain associated with rapidly conducting Aδ fibers and slowly conducting unmyelinated C fibers, respectively. First pain aims at achieving relative safety from the source of injury, whereas second pain, with its strong affective component, attracts longer-lasting attention and initiates behavioral responses in order to limit further injury and optimize recovery. Accordingly, the distinct brain representations for first and second pain should reflect distinct biological functions of both sensations.<br>   In this study, therefore, an event-related functional magnetic resonance imaging (fMRI) was used to investigate brain processing of the signals ascending from peripheral C and Aδ fibers evoked by phasic laser stimuli on the right hand in humans. The stimulation of both C and Aδ nociceptors activated the bilateral thalamus, bilateral secondary somatosensory cortex (SII), right (ipsilateral) middle insula, and bilateral Brodmann's area (BA) 24/32, with the majority of activity found in the posterior portion of the anterior cingulate cortex (pACC). However, magnitude of activity in the right (ipsilateral) BA32/8/6, including dorsal parts in the anterior portion of the ACC (aACC) and pre-supplementary motor area (pre-SMA), and the bilateral anterior insula was significantly stronger following the stimulation of C nociceptors than Aδ nociceptors. It was concluded that the activation of C nociceptors, related to second pain, evokes different brain processing from that of Aδ nociceptors, related to first pain, probably due to the differences in the emotional and motivational aspects of either pain, which are mainly related to the aACC, pre-SMA and anterior insula.

Journal

• PAIN RESEARCH

  PAIN RESEARCH 21 (3), 95-102, 2006

  JAPANESE ASSOCIATION FOR STUDY OF PAIN

Keywords

• fMRI
• Pain
• C fiber
• Aδ fiber
• ACC (anterior cingulate cortex)

Details

• CRID: 1390001204366222976
• NII Article ID: 10018071456
• NII Book ID: AN10195934
• DOI: 10.11154/pain.21.95
• ISSN: 21874697
• ISSN: 09158588
• Web Site: https://www.jstage.jst.go.jp/article/pain/21/3/21_1/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2007031484
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed