Squamous Cell Carcinoma with Dominant Dystrophic Epidermolysis Bullosa

DOI Web Site 14 References
  • Mizuno Ai
    Department of Dermatology Juntendo University Urayasu Hospital
  • Takimoto Reiko
    Department of Dermatology Juntendo University Urayasu Hospital
  • Matsuba Shoichi
    Department of Dermatology Juntendo University Urayasu Hospital
  • Shiraki Yumi
    Department of Dermatology Juntendo University Urayasu Hospital
  • Tamai Katsuto
    Division of Gene Therapy Science Osaka University Graduate School of Medicine
  • Takamori Kenji
    Department of Dermatology Juntendo University Urayasu Hospital

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  • 有棘細胞癌を合併した優性栄養障害型表皮水疱症の1例
  • ユウキョクサイボウガン オ ガッペイ シタ ユウセイ エイヨウ ショウガイガタ ヒョウヒ スイホウショウ ノ 1レイ

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Abstract

A 40-years-old man with dominant dystrophic epidermolysis bullosa (DDEB) developed a squamous cell carcinoma (SCC) on the left foot. No metastases were observed. The tumor was resected, and the wound was covered with autologous skin grafts. SCC is a frequent complication in the severe and inveterate forms of recessive dystrophic epidermolysis bullosa (RDEB); however, it is only rarely reported in the dominant type. This life-threatening complication should always be kept in mind and a biopsy taken of every chronic, non-healing ulceration and each atypical lesion in all types of epidermolysis bullosa hereditaria. We suggested that it is very important to inform patients and their relatives about this possibility and to teach them to recognize the early characteristics of SCC.

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