A Fermented Grain Food Product Extract Ameliorates Tumor Promoter-Induced Skin Oxidative Stress

• NAKAMURA Yoshimasa

  Laboratory of Food and Biodynamics, Nagoya University Graduate School of Bioagricultural Sciences Department of Biofunctional Chemistry, Division of Bioscience, Graduate School of Natural Science and Technology, Okayama University

• OSAWA Toshihiko

  Laboratory of Food and Biodynamics, Nagoya University Graduate School of Bioagricultural Sciences

抄録

We demonstrated that a dietary supplement, Antioxidant Biofactor (AOB®), a fermented grain food, inhibits phorbol ester (TPA)-induced inflammatory responses. Pretreatment of mouse skin with ethyl acetate extract of AOB (0.5mg) significantly attenuated the hydrogen peroxide level in mouse skin without inhibition of edema formation. Also, exposure of AOB extract to differentiated HL-60 cells resulted in dose-dependent inhibition of TPA-induced superoxide generation, which was stronger than those of the raw materials of AOB. Our results suggest that AOB is effective for prevention of skin oxidative stress.

収録刊行物

• Food Science and Technology Research

  Food Science and Technology Research 11 (4), 373-375, 2005

  公益社団法人 日本食品科学工学会

キーワード

• antioxidant
• phorbol ester
• oxidative stress
• mouse skin

詳細情報

• CRID: 1390282679430816128
• NII論文ID: 10018084661
• NII書誌ID: AA11320122
• DOI: 10.3136/fstr.11.373
• ISSN: 18813984
• ISSN: 13446606
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可