Antimutagenic Effect of Selenium and Vitamins Against the Genotoxicity Induced by Cobalt Chloride in Mice

• Hassan Nagwa H. A.

  Faculty of Science, Ain Shams University

• Fahmy Maha A.

  Department of Genetics and Cytology, National Research Center, Egypt

• Farghaly Ayman A.

  Department of Genetics and Cytology, National Research Center, Egypt

• Hassan Entesar E. S.

  Department of Genetics and Cytology, National Research Center, Egypt

抄録

The genotoxic effects of cobalt chloride (CoCl₂) were studied in mice using different mutagenic end points in vivo. The possible protection provided by the antioxidant selenium and vitamins (ACE) against CoCl₂ genotoxicity was also assessed. The results indicate that CoCl₂ has genotoxic effects on mice somatic and germ cells. It induced a significant increase in the frequency of chromosomal aberrations in mouse bone-marrow and spermatocytes after single and repeated oral treatments. The induction of morphological sperm abnormalities was also confirmed in the present study. The supplemental selenium and vitamins (ACE) to reduce the genotoxic effect of CoCl₂ was proved.

収録刊行物

• ＣＹＴＯＬＯＧＩＡ

  ＣＹＴＯＬＯＧＩＡ 71 (3), 213-222, 2006

  公益財団法人 日本メンデル協会

キーワード

• cobalt chloride
• genotoxicity
• selenium
• vitamins (ACE)
• mice

詳細情報

• CRID: 1390282679082676480
• NII論文ID: 10018105303
• NII書誌ID: AA00622764
• DOI: 10.1508/cytologia.71.213
• ISSN: 13487019
• ISSN: 00114545
• Web Site: http://www.jstage.jst.go.jp/article/cytologia/71/3/71_3_213/_pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可