Study on the Ophthalmic Diseases in ICR Mice and BALB/c Mice

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著者

    • Park Shin Ae PARK Shin Ae
    • Department of Veterinary Surgery and Ophthalmology, College of Veterinary Medicine, Seoul National University
    • KIM Min Su
    • Department of Veterinary Surgery and Ophthalmology, College of Veterinary Medicine, Seoul National University
    • JEONG Man Bok
    • Department of Veterinary Surgery and Ophthalmology, College of Veterinary Medicine, Seoul National University
    • SUH Jun Gyo
    • Department of Medical Genetics and Experimental Animal Center, College of Medicine, Hallym University
    • OH Yang Seok
    • Department of Medical Genetics and Experimental Animal Center, College of Medicine, Hallym University
    • WON Moo Ho
    • Department of Anatomy, College of Medicine, Hallym University
    • NAM Tchi Chou
    • Department of Veterinary Surgery and Ophthalmology, College of Veterinary Medicine, Seoul National University
    • PARK Jae Hak
    • Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University
    • SEO Kang Moon
    • Department of Veterinary Surgery and Ophthalmology, College of Veterinary Medicine, Seoul National University

抄録

In pharmaceutical companies and research institutes, many toxicity tests are performed with laboratory animals. This study was performed to produce reference data for eye toxicity tests and to investigate the ophthalmic diseases of 408 ICR mice and 119 BALB/c mice, which are commonly used as subjects in toxicity tests. The experimental animals without clinical disorders were selected regardless of sex. The ophthalmic diseases were examined by using special ophthalmic instruments: direct ophthalmoscope, indirect ophthalmoscope, slit-lamp biomicroscope and focal illuminator. The most prevalent ocular variation within normal limits was hyaloid vessel remnant (ICR mice, 28.2%; BALB/c mice, 31.9%) and the incidence gradually decreased with age. The ocular diseases found in ICR mice were retinal degeneration (9.8%), corneal scar (4.2%), focal cataract (2.2%), anisocoria (1.2%), corneal ulcer (0.2%) and uveitis (0.2%). In BALB/c mice, corneal scar (9.2%), focal cataract (1.7%) and corneal ulcer (0.8%) were the ocular diseases found.<br>

収録刊行物

  • Experimental animals  

    Experimental animals 55(2), 83-90, 2006-04-01 

    Japanese Association for Laboratory Animal Science

参考文献:  12件

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キーワード

各種コード

  • NII論文ID(NAID)
    10018114611
  • NII書誌ID(NCID)
    AA11032321
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    13411357
  • NDL 記事登録ID
    7881044
  • NDL 雑誌分類
    ZS7(科学技術--医学)
  • NDL 請求記号
    Z54-H752
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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