Study on the Ophthalmic Diseases in ICR Mice and BALB/c Mice

DOI Web Site Web Site 参考文献16件
  • PARK Shin Ae
    Department of Veterinary Surgery and Ophthalmology, College of Veterinary Medicine, Seoul National University
  • JEONG Seong Mok
    Department of Veterinary Surgery, College of Veterinary Medicine, Chungnam National University
  • YI Na Young
    Department of Veterinary Surgery and Ophthalmology, College of Veterinary Medicine, Seoul National University
  • KIM Min Su
    Department of Veterinary Surgery and Ophthalmology, College of Veterinary Medicine, Seoul National University
  • JEONG Man Bok
    Department of Veterinary Surgery and Ophthalmology, College of Veterinary Medicine, Seoul National University
  • SUH Jun Gyo
    Department of Medical Genetics and Experimental Animal Center, College of Medicine, Hallym University
  • OH Yang Seok
    Department of Medical Genetics and Experimental Animal Center, College of Medicine, Hallym University
  • WON Moo Ho
    Department of Anatomy, College of Medicine, Hallym University
  • NAM Tchi Chou
    Department of Veterinary Surgery and Ophthalmology, College of Veterinary Medicine, Seoul National University
  • PARK Jae Hak
    Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University
  • SEO Kang Moon
    Department of Veterinary Surgery and Ophthalmology, College of Veterinary Medicine, Seoul National University

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In pharmaceutical companies and research institutes, many toxicity tests are performed with laboratory animals. This study was performed to produce reference data for eye toxicity tests and to investigate the ophthalmic diseases of 408 ICR mice and 119 BALB/c mice, which are commonly used as subjects in toxicity tests. The experimental animals without clinical disorders were selected regardless of sex. The ophthalmic diseases were examined by using special ophthalmic instruments: direct ophthalmoscope, indirect ophthalmoscope, slit-lamp biomicroscope and focal illuminator. The most prevalent ocular variation within normal limits was hyaloid vessel remnant (ICR mice, 28.2%; BALB/c mice, 31.9%) and the incidence gradually decreased with age. The ocular diseases found in ICR mice were retinal degeneration (9.8%), corneal scar (4.2%), focal cataract (2.2%), anisocoria (1.2%), corneal ulcer (0.2%) and uveitis (0.2%). In BALB/c mice, corneal scar (9.2%), focal cataract (1.7%) and corneal ulcer (0.8%) were the ocular diseases found.<br>

収録刊行物

  • Experimental Animals

    Experimental Animals 55 (2), 83-90, 2006

    公益社団法人 日本実験動物学会

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