アジュバント関節炎ラットにおける超音波発信反応の痛み評価への応用 Ultrasonic Vocalization Response Elicited in Adjuvant-induced Arthritic Rats as a Useful Method for Evaluating Analgesic Drugs

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Adjuvant-induced arthritic (AIA) rats develop a severe chronic polyarthritis which shares some features in common with human rheumatoid arthritis. The purpose of the present study was to examine whether AIA rats emit ultrasonic vocalizations (USVs) when they are confronted with a healthy `stimulus rat' in social interactions. We also examined the effects of three analgesic drugs (piroxicam, rofecoxib and ketoprofen) on USV responses using the same paradigm. In social interactions, AIA rats and intact controls emitted USVs in the 22-28 kHz range. Vocalization activities were significantly higher in AIA rats than those in intact controls. Moreover, the USVs of AIA rats were significantly inhibited by the three analgesic drugs. These results suggest that the USV responses elicited in AIA rats are useful for the evaluation of analgesic drugs.<br>

収録刊行物

  • Experimental animals  

    Experimental animals 55(2), 125-129, 2006-04-01 

    Japanese Association for Laboratory Animal Science

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各種コード

  • NII論文ID(NAID)
    10018114700
  • NII書誌ID(NCID)
    AA11032321
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    13411357
  • NDL 記事登録ID
    7881128
  • NDL 雑誌分類
    ZS7(科学技術--医学)
  • NDL 請求記号
    Z54-H752
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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