テオフィリンを反復投与したF344ラットにおける顎下腺の遺伝子発現の変化 Changes in Submaxillary Gland Gene Expression in F344 Rats by Multiple Dosing of Theophylline

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Multiple exposure to theophylline, a phosphodiesterase (PDE) inhibitor, induces acinar hypertrophy in the salivary gland. This study examined the effect of theophylline on the gene expression of secretory proteins and phosphodiesterases in the submaxillary gland. Male F344 rats received saline or theophylline (50 mg/kg) intraperitoneally for 4 days. The gene expressions for the secretory protein, cystatin S (CysS), and PDE subfamilies 3A and 4D in the submaxillary gland were quantified using RT-PCR. Theophylline exposure resulted in a sustained increase in mRNA expression for CysS and PDE3A, but PDE4D gene expression was unchanged. Our results suggest that submaxillary hypertrophy is primarily caused by the enhanced transcription of CysS, and that the transcription of each PDE subfamily gene is regulated differently.<br>

収録刊行物

  • Experimental animals  

    Experimental animals 55(2), 143-146, 2006-04-01 

    Japanese Association for Laboratory Animal Science

参考文献:  14件

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各種コード

  • NII論文ID(NAID)
    10018114751
  • NII書誌ID(NCID)
    AA11032321
  • 本文言語コード
    ENG
  • 資料種別
    NOT
  • ISSN
    13411357
  • NDL 記事登録ID
    7881152
  • NDL 雑誌分類
    ZS7(科学技術--医学)
  • NDL 請求記号
    Z54-H752
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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