Clinical Evaluation of Treatments of 54 Patients with Carcinoma of the Nasal Cavity

DOI 3 Citations 27 References
  • Sakamoto Kikuo
    Department of Otolaryngology-Head and Neck Surgery, Kurume University School of Medicine
  • Takane Youko
    Department of Otolaryngology-Head and Neck Surgery, Kurume University School of Medicine
  • Miyajima Yoshimi
    Department of Otolaryngology-Head and Neck Surgery, Kurume University School of Medicine
  • Nakashima Tadashi
    Department of Otolaryngology-Head and Neck Surgery, Kurume University School of Medicine

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  • 鼻腔癌54例の臨床的検討

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Abstract

We analyzed the clinical features of 54 patients (33 males, 21 females, mean age 62 years) with carcinoma of the nasal cavity who underwent radical treatment at Kurume University Hospital between 1980 and 2003.<br>The T classification was Ti in 15 cases, T2 in 10 cases, T3 in 20 cases, and T4 in 9 cases. The N classification was NO in 52 cases and N2 in 2 cases. There were 15 stage I cases, 10 stage II cases, 19 stage III cases, and 10 stage IV cases. There were six histopathological types of tumor, and squamous cell carcinoma was the most common.<br>Surgery was performed in all 54 cases. In 18 patients, the primary disease was treated by surgery alone. In 27 cases treatment was by surgery and supportive radiotherapy. One case was treated by surgery and supportive chemotherapy. Eight cases were treated by a combination of surgery, radiotherapy, and chemotherapy.<br>The disease-specific 5-year and 10-year survival rate was 74% (T1: 77%, T2: 90%, T3: 77%, T4: 40%; Stage I: 77%, Stage II: 89%, Stage III: 83%, Stage IV: 43%). The 5-year local control rate was 76%. The disease-specific 5-year survival rate according to histopathological type was squamous cell carcinoma 65%, adenoid cystic carcinoma 83%, adenocarcinoma 100%. Local recurrence was detected in 16 cases (mean interval: 28 months). According to histopathological type, recurrence was detected in 8 cases of squamous cell carcinoma, 5 cases of adenoid cystic carcinoma, 2 cases of undifferentiated carcinoma, and 1 case of adenocarcinoma. Thirteen patients died of their primary disease (7 deaths from locoregional disease, 5 from distant metastasis, and 1 from complications).<br>The results of this retrospective review indicate the need for postoperative adjuvant radiotherapy for carcinoma of the nasal cavity and emphasize the need for both radiotherapy and chemotherapy after surgery for histopathologically high-grade malignancies.

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