Drug delivery system based on transport characteristics of biological membranes Transporter-mediated organ-specific delivery of drugs

• Sai Yoshimichi

  Department of Pharmaceutics, Kyoritsu University of Pharmacy

Bibliographic Information

Other Title

• 薬物の生体膜輸送特性とＤＤＳ　　トランスポーターを利用した臓器選択的ＤＤＳ

Abstract

A comprehensive and precise list of drug transporters has become available. Moreover, cDNA clones can be obtained easily through researchers, public resources or commercial providers. To date, substrate preferences and other functional characteristics of transporters can be studied by using in vitro expression systems. All information should be accumulated, integrated and utilized. Efficient organ-specific drug delivery should be feasible by appropriately modifying the chemical structure of drugs.<br>This review article was aimed to introduce recent success in delivery of drugs to target organs via transporters, and to discuss issues that should be considered to establish organ-specific drug delivery system.

Journal

• Drug Delivery System

  Drug Delivery System 21 (2), 111-118, 2006

  THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM

Keywords

• SLC transporters
• ABC transporters
• drug delivery
• real-time PCR
• adenovirus

Details

• CRID: 1390001204640521088
• NII Article ID: 10018118798
• NII Book ID: AN10084591
• DOI: 10.2745/dds.21.111
• COI: 1:CAS:528:DC%2BD28Xks1Cntbc%3D
• ISSN: 18812732
• ISSN: 09135006
• Web Site: https://search.jamas.or.jp/link/ui/2006148825
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed