Minimal hierarchical analysis of global human Y-chromosome SNP diversity by PCR-RFLP
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- COX MURRAY P.
- Arizona Research Laboratories-Biotechnology, University of Arizona
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Phylogenetically informative binary polymorphisms on the Y-chromosome have become a standard source of markers for molecular anthropology studies. Although several analytical methods are currently available, most methodologies rely on specialized equipment or expensive reagents that research groups with a primarily anthropological focus often cannot afford. Here I present 15 Y-chromosome lineage assays based on a more widely accessible technique—Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP). In conjunction with eight pre-existing tests, these validated protocols allow the assignment of unknown men to every major branch of the global Y-chromosome tree, including the 18 haplogroups/paragroups defined by the Y-Chromosome Consortium. While not intended to supplant the high-throughput technologies adopted by advanced research units, these minimal protocols will allow smaller molecular anthropology groups to survey male variation in a broader range of human populations, thereby furthering our understanding of global human Y-chromosome diversity.<br>
収録刊行物
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- Anthropological Science
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Anthropological Science 114 (1), 69-74, 2006
一班社団法人 日本人類学会
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詳細情報 詳細情報について
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- CRID
- 1390282679288249472
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- NII論文ID
- 10018120657
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- NII書誌ID
- AA11307827
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- ISSN
- 13488570
- 09187960
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- NDL書誌ID
- 7883990
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可